Starvation stress-responsive transcription factor is involved in the regulation of memory-independent social behavior of mouse

激活转录因子5 （activated Transcription Factor 5, ATF5）是一种饥饿诱导的应激反应转录因子，在脑室下区强烈表达，每周在大范围的脑内表达。嗅觉上皮中的嗅觉神经元也大量表达ATF5。我们制作了atf5缺陷基因小鼠，用它们测试行为特征，包括焦虑、毅力、社交、工作记忆和参考记忆。缺乏atf5的小鼠表现出多动、强烈焦虑、社交活动抑郁和较强的坚持倾向，不依赖于工作记忆和参考记忆。这些行为特征表明，atf5缺陷小鼠表现出自闭症谱系样的行为异常。对ATF5缺失小鼠嗅球的组织化学检查发现，ATF5参与了气味感知的神经活动。

Activating Transcription Factor 5 (ATF5), starvation-induced stress-responsive transcription factor, is expressed strongly in the subventricular zone and weekly in the wide range of the brain. Olfactory neurons in olfactory epithelium also express ATF5 abundantly. We made ATF5-deficent congenic mice and used them to test behavioral characteristics, including anxiety, perseveration, social contact, working memory and reference memory. ATF5-deficient mice showed hyperactivity, strong anxiety, depressed social activity and strong tendency of perseveration, independent of working and reference memories. These behavioral features indicate that ATF5-deficient mice show autism spectrum-like behavioral abnormality. Histochemical examination of the odorant bulb of ATF5-defficient mice revealed that ATF5 is involved in the neural activity of odorant perception.