Starvation stress-responsive transcription factor is involved in the regulation of memory-independent social behavior of mouse

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Activating Transcription Factor 5 (ATF5), starvation-induced stress-responsive transcription factor, is expressed strongly in the subventricular zone and weekly in the wide range of the brain. Olfactory neurons in olfactory epithelium also express ATF5 abundantly. We made ATF5-deficent congenic mice and used them to test behavioral characteristics, including anxiety, perseveration, social contact, working memory and reference memory. ATF5-deficient mice showed hyperactivity, strong anxiety, depressed social activity and strong tendency of perseveration, independent of working and reference memories. These behavioral features indicate that ATF5-deficient mice show autism spectrum-like behavioral abnormality. Histochemical examination of the odorant bulb of ATF5-defficient mice revealed that ATF5 is involved in the neural activity of odorant perception.