Nonalcoholic steatohepatitis induced by the excess ingestion of fructose and its prevention by functional foods ingredient

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When KK-Ay mice were fed a high-sucrose or high-fructose diet, the growth of Bifidobacterium in cecum was suppressed. The change in microflora may associate with the pathology of nonalcoholic steatohepatitis induced by the excess ingestion of fructose, as well as the case of the ingestion of high-fat diets.From eucalyptus extract, tellimagrandin I, a kind of ellagitannins, was isolated as an inhibitor for intestinal fructose absoption. In addition to eucalyptus extract, banaba, guava and olive extracts also inhibited intestinal fructose absorption and suppressed adiposity induced by the excess ingestion of fructose in rats.