Eucalyptus polyphenols inhibit intestinal fructose absorption, prevent adiposity, and improve diabetes mellitus

蔗糖比淀粉更容易产生脂肪，过量摄入蔗糖会导致肥胖和肥胖。本研究旨在探讨桉树（eucalyptus globulus）叶提取物（ELE）对饮食中蔗糖引起的肥胖大鼠的影响。此外，本研究还考察了ELE对肠道果糖吸收的影响。大鼠分别饲喂高糖（75%热量基础）饲粮，添加或不添加ELE （10 g/kg饲粮）5周。接受ELE治疗的大鼠体重低于对照组(342 g (SD 37.9) vs 392 g (SD 26.0) g (n 7)；P < 0.05)。此外，ELE导致血浆中甘油三酯浓度降低(1.44 (SD 0.448) vs 2.79 (SD 0.677) mmol/l (n 7)；P<0.05)和肝脏(19.1 (SD 5.07) vs . 44.1 (SD 16.28) μmol/g (n 7)；P < 0.05)。相比之下，在喂食淀粉的老鼠身上，ELE没有显示出任何显著的影响。当大鼠在给果糖前10分钟口服ELE时，通过测量给果糖后30 mm门静脉中果糖浓度的升高来检测肠道果糖吸收，并以剂量依赖的方式显着抑制。此外，饲喂高果糖饮食的大鼠血浆和肝脏甘油三酯浓度显著降低。这些结果表明，抑制肠道果糖吸收的ELE可以抑制摄入大量蔗糖或果糖的大鼠的肥胖。

Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75% in calorie base) with or without ELE (10 g/kg of diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (SD 37.9) versus 392 (SD 26.0) g (n 7) ; P<0.05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1.44 (SD 0.448) versus 2.79 (SD 0.677) mmol/l (n 7) ; P<0.05) and liver (19.1 (SD 5.07) versus 44.1 (SD 16.28) μmol/g (n 7) ; P<0.05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 mm after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, that inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.