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Eucalyptus polyphenols inhibit intestinal fructose absorption, prevent adiposity, and improve diabetes mellitus

桉树多酚抑制肠道果糖吸收，预防肥胖，改善糖尿病

基本信息

批准号：
14560107
负责人：
INUI Hiroshi
金额：
$ 2.18万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75% in calorie base) with or without ELE (10 g/kg of diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (SD 37.9) versus 392 (SD 26.0) g (n 7) ; P<0.05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1.44 (SD 0.448) versus 2.79 (SD 0.677) mmol/l (n 7) ; P<0.05) and liver (19.1 (SD 5.07) versus 44.1 (SD 16.28) μmol/g (n 7) ; P<0.05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 mm after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, that inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.

蔗糖比淀粉更容易产生脂肪，过度摄入蔗糖会导致肥胖和肥胖。本研究的目的是检查桉树（蓝桉）叶提取物（ELE）对大鼠膳食蔗糖引起的肥胖的影响。此外，本研究还考察了ELE对肠道果糖吸收的影响。大鼠喂食高蔗糖饮食（75%的热量基础）与或不ELE（10克/公斤的饮食）5周。ELE组大鼠体重低于对照组（342（SD 37.9）vs 392（SD 26.0）g（n 7）; P<0.05）。此外，ELE导致血浆（1.44（SD 0.448）vs 2.79（SD 0.677）mmol/l（n 7）; P<0.05）和肝脏（19.1（SD 5.07）vs 44.1（SD 16.28）μmol/g（n 7）; P<0.05）中三酰甘油浓度降低。相反，ELE在喂食淀粉饮食的大鼠中没有显示出任何显著的影响。当大鼠在果糖给药前10分钟口服ELE时，通过测量果糖给药后30 mm门静脉中果糖浓度升高来检查的肠道果糖吸收以剂量依赖性方式被显著抑制。此外，在喂食高果糖饮食的大鼠中，ELE显著降低了血浆和肝脏三酰甘油浓度。这些结果表明，抑制肠道果糖吸收的ELE可以抑制摄入大量蔗糖或果糖的大鼠的肥胖。