Search of the seeds of an antineoplastic drug and development of a lead compound which marine organism origin fungi produce

我们研究了从各种海洋生物中分离出来的真菌产生的代谢物。从海绵状真菌中分离到了3个新化合物，并建立了1个代谢产物的绝对立体结构。从一种海胆源真菌中分离到一个新的化合物，并推导出其平面结构。为了确定它的绝对构型，进行了几个化学反应，并将很快进行竞争。我们对产生细胞毒性物质的真菌进行了成功的研究。因此，许多新物质被分离出来，其中一些物质显示出对癌细胞生长的有效抑制作用。

We studied the metabolites produced the fungi separated from the various marine organizaition. New three compounds were isolated from the marine sponge-derived fungus, and the absolute stereostructure for one metabolites was established. A novel compound was isolated from a sea urchin-derived fungus, and the planar structure was deduced. In order to the detrermination for the absolute configuration of it, several chemical reactions were carried out, and will copmpete soon. We scrutinized succeedingly about the cytotoxic substance production fungus. Consequently, many new substances were isolated and some of them demonstrated potent activities for the growth inhibition against the cancer cell lines.