Research on active compounds from natural resources affecting the differentiation of ES and iPS cells

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Several new compounds were isolated from plant sources together with known compounds. The structures of the new compounds were elucidated by spectroscopic analyses. Several of the isolated compounds exhibited the following useful biological activities: severibuxine, murrayafoline-A, and murrayazolinine significantly suppressed the growth of HL-60 leukemia cells by causing apoptosis; lansamide I, lansiumamide B, and SB-204900 significantly decreased histamine release from RBL-2H3 cells; and lapachol decreased the proliferation rate of hypertrophic scar fibroblasts. Aromatic compounds produced by Eurotium herbariorum from a karebushi were isolated; of these, several benzaldehyde derivatives exhibited high radical scavenging activity. Three carbazolequinone derivatives, synthesized using murrayaquinone-A as a lead compound, inhibited LPS/IFN-induced NO production. No seed compounds affecting the differentiation of ES and iPS cells have been found; however, future research is planned.