Research on active compounds from natural resources affecting the differentiation of ES and iPS cells

自然资源中影响 ES 和 iPS 细胞分化的活性化合物的研究

基本信息

批准号：
23590026
负责人：
ITO CHIHIRO
金额：
$ 3.33万
依托单位：
Meijo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

Several new compounds were isolated from plant sources together with known compounds. The structures of the new compounds were elucidated by spectroscopic analyses. Several of the isolated compounds exhibited the following useful biological activities: severibuxine, murrayafoline-A, and murrayazolinine significantly suppressed the growth of HL-60 leukemia cells by causing apoptosis; lansamide I, lansiumamide B, and SB-204900 significantly decreased histamine release from RBL-2H3 cells; and lapachol decreased the proliferation rate of hypertrophic scar fibroblasts. Aromatic compounds produced by Eurotium herbariorum from a karebushi were isolated; of these, several benzaldehyde derivatives exhibited high radical scavenging activity. Three carbazolequinone derivatives, synthesized using murrayaquinone-A as a lead compound, inhibited LPS/IFN-induced NO production. No seed compounds affecting the differentiation of ES and iPS cells have been found; however, future research is planned.

从植物来源分离出几种新化合物以及已知化合物。通过光谱分析阐明了新化合物的结构。几种孤立的化合物表现出以下有用的生物学活性：严重比毒，Murrayafoline-A和Murrayazolinine通过引起凋亡显着抑制HL-60白血病细胞的生长； Lansamide I，Lansiumamide B和SB-204900显着降低了从RBL-2H3细胞释放组胺。拉帕醇降低了肥厚疤痕成纤维细胞的增殖率。孤立了由karebushi的Eurotium Herbariorum生产的芳香化合物；其中，几种苯甲醛衍生物表现出很高的自由基清除活性。使用Murrayaquinone-A作为铅化合物合成的三种甲唑喹酮衍生物抑制了LPS/IFN诱导的NO产生。尚未发现影响ES和IPS细胞分化的种子化合物。但是，计划未来的研究。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia

九里香咔唑生物碱诱导HL-60白血病细胞凋亡

DOI：
发表时间：
2012
期刊：
J. Nat. Med
影响因子：
0
作者：
Chihiro Ito;Masataka Itoigawa;Keisuke Nakao;Tomiyasu Murata;Norio Kaneda;Hiroshi Furukawa
通讯作者：
Hiroshi Furukawa

Natsudaidain isolated from Citrus plants inhibits activation of mast cells in the late phase of immediate allergy

从柑橘类植物中分离出的 Natsudaidain 可抑制即时过敏后期肥大细胞的活化

DOI：
发表时间：
2013
期刊：
影响因子：
0
作者：
Takuya Matsui;Hiroyuki Shiono;Chihiro Ito;Masataka Itoigawa;Tadashi Okada
通讯作者：
Tadashi Okada

Inhibitory effect of carbazolequinone derivatives on lipopolysaccharide and interferon-γ- induced nitric oxide production in mouse macrophage RAW264.7 cells

咔唑醌衍生物对脂多糖和干扰素-γ诱导的小鼠巨噬细胞RAW264.7细胞一氧化氮产生的抑制作用

DOI：
发表时间：
2013
期刊：
J. Pharm. Pharmacol
影响因子：
0
作者：
Tomiyasu Murata;Susumu Kohno;Chihiro Ito;Masataka Itoigawa;Ayumi Sugiura;Kiyomi Hikita;Norio Kaneda
通讯作者：
Norio Kaneda

Flavonoid, Phenylpropanoid and Coumarins Characteristics in Lemons from the Bonin Islands (Kikuchi Lemons)

小笠原群岛柠檬（菊池柠檬）中的类黄酮、苯丙素和香豆素特征