Role of cytochrome c as a novel signaling molecule by the investigation of LRG knock-out mouse

点击翻译按钮获取中文摘要

Leucine-rich alpha2-glycoprotein (LRG), one of the serum proteins with unknown function, was found to bind tightly and form complex with the extracellular cytochrome c (Cytc). The positive charges of the residues 8, 13, 72, 73, and 79 of Cytc molecule were important to this binding. A Cytc-LRG complex would function as a danger signal that modulates the immune cells such as bone marrow-derived macrophages to induce G-CSF expression, leading to the neutrophil proliferation in bone marrow.