Effects of monoamine on the prefrontal cortical neurons and amygdaloid nuclei neurons

单胺对前额皮质神经元和杏仁核神经元的影响

• 批准号: 23590269
• 负责人: TANAKA Eiichiro
• 金额: $ 2.33万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590269/
• 关键词: 受容体; 細胞内シグナル伝達; シナプス伝達; 前頭前野; field EPSP; GABAA受容体; ドーパミン; テタヌス刺激; 長期増強; 長期抑制; 第II-III層; ニューロン; 静止電位; ドパミン; シナプス電流; 第II - III層; 錐体細胞; 多形細胞; 活動電位; シナプス電位

Superfusion of dopamine (10 micro M) induced depolarization with reduction in input resistance in 15% of pyramidal neurons and in 27% of multipolar neurons of the II - III layer of prefrontal cortex in rats, which was mediated by dopamine D2 like receptors. Low concentration (0.1 micro M) of dopamine increased and high concentration (100 micro M) of dopamine decreased the amplitude of fast excitatory and fast inhibitory synaptic potentials (EPSPs and IPSPs). A D2 like receptor agonist reduced the amplitude of fast inhibitory synaptic currents more effectively than the amplitude of fast excitatory synaptic currents, indicating that disinhibition might induce the increase in fast EPSPs. Electrical tetanus stimuli induced long-term inhibition of field EPSPs and the simultaneous application of dopamine (100 micro M) and tetanus stimuli induced long-term potentiation of field EPSPs, therefore, presence of dopamine might contribute to the cognition and memory in the prefrontal cortex.

多巴胺（10 μ M）的灌流在大鼠的前额叶皮层的II-III层的15%锥体神经元和27%多极神经元中诱导去极化，其中输入电阻降低，这是由多巴胺D2样受体介导的。低浓度（0.1 μ M）多巴胺增加，高浓度（100 μ M）多巴胺降低快速兴奋性和快速抑制性突触电位（EPSP和IPSP）的振幅。D2样受体激动剂降低快抑制性突触电流的幅度比快兴奋性突触电流的幅度更有效，表明去抑制可能引起快EPSP的增加。电强直刺激引起长时程抑制的场EPSP和多巴胺（100 μ M）和强直刺激的同时应用引起的场EPSP的长时程增强，因此，多巴胺的存在可能有助于在前额叶皮层的认知和记忆。

项目成果

Activation of protein kinase A contributes to the persistent depolarization induced by in vitro ischemia

蛋白激酶 A 的激活有助于体外缺血诱导的持续去极化

• 发表时间: 2011
• 作者: Murai Y;Tanaka E
• 通讯作者: Tanaka E

Clinical neuroprotective drugs for treatment and prevention of stroke.

• DOI: 10.3390/ijms13067739
• 发表时间: 2012
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Kikuchi K;Uchikado H;Morioka M;Murai Y;Tanaka E
• 通讯作者: Tanaka E

Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons.

蛋白激酶 A 和 C 的激活可防止大鼠海马神经元因缺氧和缺糖而产生的持续去极化恢复。

• DOI: 10.1152/jn.00537.2011
• 发表时间: 2012
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Y. Murai;Y. Okabe;E. Tanaka
• 通讯作者: E. Tanaka

Electrophysiological analysis of RTT model ES cell-derived neurons

RTT模型ES细胞源性神经元的电生理分析

• 发表时间: 2011
• 作者: Okabe Y;Kusaga A;Takahashi T;Mitsumasu C;Murai Y;Higashi H;Matsuishi T;Kosai K;Tanaka E
• 通讯作者: Tanaka E

Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.

• DOI: 10.3390/ijms140918899
• 发表时间: 2013-09-13
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Kikuchi K;Tancharoen S;Ito T;Morimoto-Yamashita Y;Miura N;Kawahara K;Maruyama I;Murai Y;Tanaka E
• 通讯作者: Tanaka E