Effects of monoamine on the prefrontal cortical neurons and amygdaloid nuclei neurons

多巴胺（10 μ M）的灌流在大鼠的前额叶皮层的II-III层的15%锥体神经元和27%多极神经元中诱导去极化，其中输入电阻降低，这是由多巴胺D2样受体介导的。低浓度（0.1 μ M）的多巴胺增加和高浓度（100 μ M）的多巴胺降低快速兴奋性和快速抑制性突触电位（EPSP和IPSP）的幅度。D2样受体激动剂降低快抑制性突触电流的幅度比快兴奋性突触电流的幅度更有效，表明去抑制可能引起快EPSP的增加。电强直刺激引起长时程抑制的场EPSP和多巴胺（100 μ M）和强直刺激的同时应用引起的场EPSP的长时程增强，因此，多巴胺的存在可能有助于在前额叶皮层的认知和记忆。

Superfusion of dopamine (10 micro M) induced depolarization with reduction in input resistance in 15% of pyramidal neurons and in 27% of multipolar neurons of the II - III layer of prefrontal cortex in rats, which was mediated by dopamine D2 like receptors. Low concentration (0.1 micro M) of dopamine increased and high concentration (100 micro M) of dopamine decreased the amplitude of fast excitatory and fast inhibitory synaptic potentials (EPSPs and IPSPs). A D2 like receptor agonist reduced the amplitude of fast inhibitory synaptic currents more effectively than the amplitude of fast excitatory synaptic currents, indicating that disinhibition might induce the increase in fast EPSPs. Electrical tetanus stimuli induced long-term inhibition of field EPSPs and the simultaneous application of dopamine (100 micro M) and tetanus stimuli induced long-term potentiation of field EPSPs, therefore, presence of dopamine might contribute to the cognition and memory in the prefrontal cortex.