Effects of monoamine on the prefrontal cortical neurons and amygdaloid nuclei neurons

多巴胺（10 μ M）过量诱导大鼠额叶皮层II - III层锥体神经元和27%多极神经元去极化并减少输入电阻，这是由多巴胺D2样受体介导的。低浓度（0.1微M）多巴胺增加，高浓度（100微M）多巴胺降低了快速兴奋性和快速抑制性突触电位（EPSPs和IPSPs）的振幅。D2样受体激动剂对快速抑制性突触电流振幅的抑制作用大于对快速兴奋性突触电流振幅的抑制作用，表明去抑制可能诱导快速epsp的增加。破伤风电刺激引起脑区epsp的长期抑制，多巴胺（100 μ M）与破伤风电刺激同时作用引起脑区epsp的长期增强，因此多巴胺的存在可能与前额叶皮层的认知和记忆有关。

Superfusion of dopamine (10 micro M) induced depolarization with reduction in input resistance in 15% of pyramidal neurons and in 27% of multipolar neurons of the II - III layer of prefrontal cortex in rats, which was mediated by dopamine D2 like receptors. Low concentration (0.1 micro M) of dopamine increased and high concentration (100 micro M) of dopamine decreased the amplitude of fast excitatory and fast inhibitory synaptic potentials (EPSPs and IPSPs). A D2 like receptor agonist reduced the amplitude of fast inhibitory synaptic currents more effectively than the amplitude of fast excitatory synaptic currents, indicating that disinhibition might induce the increase in fast EPSPs. Electrical tetanus stimuli induced long-term inhibition of field EPSPs and the simultaneous application of dopamine (100 micro M) and tetanus stimuli induced long-term potentiation of field EPSPs, therefore, presence of dopamine might contribute to the cognition and memory in the prefrontal cortex.