Functional analysis of the novel modulator of gamma secretase

最近的报告显示，460万日本人患有痴呆症，400多万日本人有轻微的认知障碍。病因学研究的巨大数字让我们感到惊讶，在日本以及老年人口不断增加的国家，人们强烈希望建立阿尔茨海默病的基本治疗方法。大量证据表明-淀粉样蛋白的增加是罪魁祸首。在小鼠中产生的基因调节模拟了AD脑病理并恶化了认知功能。本研究鉴定了一种新的β产生酶的调节蛋白。确定的调制器是特定于Abeta生产的，而不是另一个关键的Notch生产。我们还证实了这种新型调节剂的转基因小鼠减少了小鼠大脑中β的产生。这些发现表明所鉴定的调节剂是阿尔茨海默病的治疗靶点。

The recent report revealed that 4.6 million Japanese suffer with dementia and more than 4 million, with minimal cognitive impairment. This huge number by this etiological research surprised us and the establishment of fundamental therapeutics of Alzheimer's disease is strongly desired in Japan as well as in the countries where the aged are increasing. A lot of evidence have realized that the increase in amyloid beta is a culprit. The genetic modulation of Abeta production in mice mimics the AD brain pathology and deteriorates the cognitive function. This study identified the novel modulating protein of Abeta producing enzyme. The identified modulator is specific to Abeta production, not to another pivotal Notch production. We also confirmed that transgenic mouse of the novel modulator decreased Abeta production in the mouse brain. These findings suggest that the identified modulator is a therapeutic target of AD.