Malaria vaccine platform technology

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Development of subunit vaccines to prevent malaria infection has been hampered by the intrinsic weak immunogenicity of the recombinant malaria antigens. We have establised a novel system called tricomponent immunopotentiating system (TIPS) to increase immune responses by creating genetic protein fusions to target B lymphocytes in the draining lymph nodes of immunized animals. TIPS is composed of the antigen, coiled-coil core and the targeting ligand. We found that integration of vaccine antigens in the TIPS significantly augmented the immunogenicity and vaccine efficacy of the antigens.