Elucidation of interorganelle network in RLRs-mediated innate immunity

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Crucial role of mitochondria has been proven in RLRs (RIG-I-like receptors)-mediated antiviral signaling pathway. Organelles including mitochondria are known to form interorganelle network. We investigated the formation of the interorganelle network in the RLRs-mediated antiviral signaling. We found that some organelles were close upon activation of the antiviral signaling; however no contact between goldi or endosomes and mitochondria was observed in response to dsRNA introduction. These results suggested that transduction of signaling molecules may be essential in the interorganelle network.