Elucidation of interorganelle network in RLRs-mediated innate immunity

阐明 RLR 介导的先天免疫中的细胞器间网络

• 批准号: 23590560
• 负责人: MATSUMIYA Tomoh
• 金额: $ 3.33万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590560/
• 关键词: 自然免疫; ウイルス学; 細胞生物学; ミトコンドリア; 抗ウイルスシグナル; RLR; ウイルスセンサー; 細胞小器官; 細胞内小器官; RLRs

Crucial role of mitochondria has been proven in RLRs (RIG-I-like receptors)-mediated antiviral signaling pathway. Organelles including mitochondria are known to form interorganelle network. We investigated the formation of the interorganelle network in the RLRs-mediated antiviral signaling. We found that some organelles were close upon activation of the antiviral signaling; however no contact between goldi or endosomes and mitochondria was observed in response to dsRNA introduction. These results suggested that transduction of signaling molecules may be essential in the interorganelle network.

线粒体在 RLR（RIG-I 样受体）介导的抗病毒信号通路中的关键作用已被证明。 已知包括线粒体在内的细胞器形成细胞器间网络。 我们研究了 RLR 介导的抗病毒信号传导中细胞器间网络的形成。 我们发现一些细胞器在抗病毒信号激活时处于关闭状态；然而，没有观察到 Goldi 或内体与线粒体之间因 dsRNA 引入而发生接触。 这些结果表明信号分子的转导可能在细胞器间网络中至关重要。

项目成果

Involvement of neuronal differentiation in intracellular antiviral responses.

神经元分化参与细胞内抗病毒反应。

• 发表时间: 2012
• 作者: Tomoh Matsumiya;Ryo Hayakari;Tadaatsu Imaizumi and Hidemi Yoshida
• 通讯作者: Tadaatsu Imaizumi and Hidemi Yoshida

Role of type I- and type II-interferon in expression of melanoma differentiation-associated gene-5 in HSC-3 oral squamous carcinoma cells

• DOI: 10.2220/biomedres.35.9
• 发表时间: 2014-02-01
• 期刊: BIOMEDICAL RESEARCH-TOKYO
• 影响因子: 1.2
• 作者: Kon, Takao;Matsumiya, Tomoh;Kimura, Hiroto
• 通讯作者: Kimura, Hiroto

Biphasic STAT1 phosphorylation in response to double-stranded RNA

双链 STAT1 磷酸化响应双链 RNA

• 发表时间: 2013
• 作者: Matsumiya T;Dempoya J;Xing F;Hayakari R;Imaizumi T;Yoshida H;Satoh K
• 通讯作者: Satoh K

Basic-helix-loop-helix transcription factor DEC2 constitutes negative feedback loop in IFN-β-mediated inflammatory responses in human mesangial cells

• DOI: 10.1016/j.imlet.2010.11.009
• 发表时间: 2011-04-30
• 期刊: IMMUNOLOGY LETTERS
• 影响因子: 4.4
• 作者: Imaizumi, Tadaatsu;Sato, Fuyuki;Satoh, Kei
• 通讯作者: Satoh, Kei

Polyinosinic-Polycytidylic Acid Induces the Expression of Interferon-Stimulated Gene 20 in Mesangial Cells

• DOI: 10.1159/000328923
• 发表时间: 2011-01-01
• 期刊: NEPHRON EXPERIMENTAL NEPHROLOGY
• 作者: Imaizumi, Tadaatsu;Tanaka, Hiroshi;Satoh, Kei
• 通讯作者: Satoh, Kei