Effects of n-3 unsaturated fatty acid on ischemic heart disease: evaluation of LDL choesterol function

点击翻译按钮获取中文摘要

Hypertriglyceridemic subjects were randomly assigned to a control group or an EPA group.In the EPA group,the serum LDL-C and HDL-C levels remained unchanged, but there was a significant increase in LDL size and a significant decrease in TG-rich lipoproteins (TRLs) levels. Elevation of EPA/AA was independent variable associated with the increase in LDL size. Negative correlations were found between TRLs and LDL particle size. EPA administration increases LDL size by improving TG metabolism, and EPA/AA may be useful markers of increased LDL size.The cross-sectional study suggested that higher serum levels of EPA and DHA derived from fish consumption are associated with lower coronary artery disease prevalence even in an urban environment in Japan. Higher EPA and DHA levels were independent variables of a higher apoA-1 level.