Effects of n-3 unsaturated fatty acid on ischemic heart disease: evaluation of LDL choesterol function

n-3不饱和脂肪酸对缺血性心脏病的影响：评估LDL胆固醇功能

• 批准号: 23590757
• 负责人: TANI Shigemasa
• 金额: $ 3.33万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590757/
• 关键词: エイコサペンタエン酸; ドコサヘキサエン酸; 冠動脈疾患; 血清脂質; n-3系不飽和脂肪酸; リポタンパクコレステロール

Hypertriglyceridemic subjects were randomly assigned to a control group or an EPA group.In the EPA group,the serum LDL-C and HDL-C levels remained unchanged, but there was a significant increase in LDL size and a significant decrease in TG-rich lipoproteins (TRLs) levels. Elevation of EPA/AA was independent variable associated with the increase in LDL size. Negative correlations were found between TRLs and LDL particle size. EPA administration increases LDL size by improving TG metabolism, and EPA/AA may be useful markers of increased LDL size.The cross-sectional study suggested that higher serum levels of EPA and DHA derived from fish consumption are associated with lower coronary artery disease prevalence even in an urban environment in Japan. Higher EPA and DHA levels were independent variables of a higher apoA-1 level.

将高脂血症患者随机分为对照组和EPA组，EPA组的血清LDL-C和HDL-C水平保持不变，但LDL大小显著增加，富含TG的脂蛋白（TRL）水平显著降低。EPA/AA升高是与LDL大小增加相关的独立变量。TRLs与LDL颗粒大小呈负相关。EPA管理通过改善TG代谢增加LDL大小，EPA/AA可能是增加LDL大小的有用标记物。横截面研究表明，即使在日本的城市环境中，来自鱼类消费的较高血清EPA和DHA水平与较低的冠状动脉疾病患病率相关。较高的EPA和DHA水平是较高的apoA-1水平的独立变量。

项目成果

Association of N-3 Polyunsaturated Fatty Acids and Coronary Artery Disease Morbidity with Atherosclerosis-Related Markers

N-3 多不饱和脂肪酸和冠状动脉疾病发病率与动脉粥样硬化相关标志物的关联

• 发表时间: 2013
• 作者: Tani;Nagao;Kawamata;Furuya;Takahashi;Iida;Matsumoto;Kobari;Washio;Kazato;Hirayama
• 通讯作者: Hirayama

EPA/AA比は冠動脈疾患の予防に有用か？

EPA/AA 比率对于预防冠状动脉疾病有用吗？

• 作者: 櫻井拓也;小笠原準悦;木崎節子;長澤純一;芳賀脩光;大野秀樹;谷 樹昌
• 通讯作者: 谷 樹昌

平山内科パネルディスカッション2:冠動脈イベントを予測できるか?血清エイコサペンタエン酸/アラキドンサン酸(EPA/AA)比は冠動脈疾患発症の予測バイオマーカーになるか

平山内科小组讨论 2：可以预测冠状动脉事件吗？血清二十碳五烯酸/花生四烯酸 (EPA/AA) 比率是冠状动脉疾病发生的预测生物标志物吗？

• 发表时间: 2012
• 作者: 谷;長尾;川俣;古屋;高橋;飯田;松本;小張;鷲尾;風戸
• 通讯作者: 風戸

Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome

• DOI: 10.1016/j.amjcard.2013.10.011
• 发表时间: 2014-02-01
• 期刊: AMERICAN JOURNAL OF CARDIOLOGY
• 影响因子: 2.8
• 作者: Nishizaki, Yuji;Shimada, Kazunori;Daida, Hiroyuki
• 通讯作者: Daida, Hiroyuki

Highly Purified Eicosapentaenoic Acid May Increase Low-Density Lipoprotein Particle Size by Improving Triglyceride Metabolism in Patients With Hypertriglyceridemia

• DOI: 10.1253/circj.cj-12-1401
• 发表时间: 2013-09-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Tani, Shigemasa;Nagao, Ken;Hirayama, Atsushi
• 通讯作者: Hirayama, Atsushi