A study on protective ability of a traditional Japanese herbal medicine against oxidative skin stress

日本传统草药对皮肤氧化应激的保护能力研究

• 批准号: 23590892
• 负责人: KOBAYASHI Hiromi
• 金额: $ 3.41万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590892/
• 关键词: 補中益気湯; 紫外線; 皮膚; 酸化ストレス; 漢方

Hochuekkito, a traditional Japanese herbal (Kampo) medicine composed of 10 kinds of crude drugs including Astragalus, Ginseng and Bupleurum, has been used for improvement of functional deterioration of the various organs. A randomized control trial has demonstrated its value in the treatment of atopic dermatitis. In this study, we evaluated the functional and histopathological effects of hochuekkito on ultraviolet B (UVB) irradiated mice skin to examine its protective ability against oxidative skin stress. Hochuekkito comprehensively offered a protective effect against UV-B induced skin damage.

Hochuekkito是一种传统的日本草药（汉方），由包括黄芪、人参和柴胡在内的10种原料药组成，已用于改善各种器官的功能恶化。一项随机对照试验已证明其在治疗特应性皮炎中的价值。在这项研究中，我们评估了hochuekkito对紫外线B（UVB）照射的小鼠皮肤的功能和组织病理学的影响，以检查其对皮肤氧化应激的保护能力。Hochuekkito全面提供了对UV-B引起的皮肤损伤的保护作用。

项目成果

Protective effects of a Kampo prescription, hochuekkito, against ultraviolet B-induced oxidative stress in hairless mice skin

汉方处方 hochuekkito 对无毛小鼠皮肤中紫外线 B 诱导的氧化应激的保护作用

• 发表时间: 2011
• 作者: Kobayashi H;Yanagihara S;Tamiya H;Tsuruta D;Okano Y;Takahashi K;Masaki H;Yamada T;Hasegawa S;Akamatsu H;Ishii M
• 通讯作者: Ishii M

紫外線照射による皮膚酸化ストレスと形態学的変化に対する補中益気湯の抑制効果

Hochuekkito 对紫外线照射引起的皮肤氧化应激和形态变化的抑制作用

• 发表时间: 2013
• 作者: 柳原茂人;小林裕美;田宮久詩;岡野由利;鶴田大輔;高橋邦明;森亮太;正木仁;山田貴亮;長谷川靖司;赤松浩彦;石井正光
• 通讯作者: 石井正光

Hochuekkito, a Kampo prescription reduced skin oxidative stress indirectly in ultraviolet B-irradiated mice skin

Hochuekkito，一种汉方处方，可间接降低紫外线 B 照射小鼠皮肤的氧化应激

• 作者: Yanagihara S;Kobayashi H;Tamiya H;Tsuruta S;Nakanishi T;Okano Y;Masaki H;Yamada T;Hasegawa S;Ishii M
• 通讯作者: Ishii M

Histopathological study of the effects of Astragalus, Bupleurum and Ginseng combination formula, Hochuekkito, a traditional Japanese herbal medicine, on ultraviolet-irradiated skin damage in hairless mice

黄芪、柴胡和人参组合配方（日本传统草药 Hochuekkito）对无毛小鼠紫外线照射皮肤损伤影响的组织病理学研究

• 发表时间: 2013
• 作者: Hiromi Kobayashi;Shigeto Yanagihara;Hisashi Tamiya;Daisuke Tsuruta;Yuri Okano;Kuniaki Takahashi;Hitoshi Masaki;Takaaki Yamada;Seiji Hasegawa;Hirohiko Akamatsu;Masamitsu Ishii
• 通讯作者: Masamitsu Ishii

A “healthy, low-calorie diet” session for the treatment of recalcitrant atopic dermatitis

治疗顽固性特应性皮炎的“健康、低热量饮食”课程

• 发表时间: 2012
• 作者: Kobayashi H;Tamiya H; Yanagihara S;Aoki A;Hoshi K;Naruse A;Tateishi C;Nakanishi T;Tsuruta D;Ishii M
• 通讯作者: Ishii M