Research on the therapeutic and preventive effects of alternative medicine in senile osteoporosis

替代医学治疗老年骨质疏松症的治疗和预防作用研究

• 批准号: 23590899
• 负责人: NASU Fumio
• 金额: $ 3.24万
• 依托单位: Suzuka University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590899/
• 关键词: 老人性骨粗鬆症; SAMP6; 鍼; 灸; 補完代替医療; Glutation Peroxidase; AGEs; ホモシステイン; osteoporosis; SAM

The senescence accelerated mouse strain P6 (SAMP6) is a model of senile osteoporosis because it develops osteoporosis in an early stage of life. We investigated the effects of traditional Chinese medicine, acupuncture and moxibustion, on mechanical properties of femur in SAMP6 mice by using the 3-point bending.Male SAMP6 mice received acupuncture or moxibustion stimulation on the bilateral Zusanri (anterior tibial muscle at about 10 mm below the knee joint) for at least 8 weeks. The strength of the femur tended to increase in the acupuncture SAMP6 group compared with the control SAMP6 group. However such effect was not recognized in the moxibustion SAMP6 group.We further evaluated the quality of bone which influences bone strength. We employed a level of antioxidative effect and non-physiological binding in bone collagen. Neither acupuncture nor moxibusion has influence on the quality of bone.

衰老加速小鼠品系P6 （SAMP6）是一种老年性骨质疏松的模型，因为它在生命的早期就发生了骨质疏松。采用三点弯曲法研究中药、针灸对SAMP6小鼠股骨力学性能的影响。雄性SAMP6小鼠接受双侧足三里（膝关节下约10mm的胫骨前肌）针刺或艾灸刺激至少8周。针刺SAMP6组与对照SAMP6组相比，股骨强度有增加的趋势。而在SAMP6艾灸组没有发现这种效果。我们进一步评估了影响骨强度的骨质量。我们在骨胶原中使用了一定程度的抗氧化作用和非生理性结合。针灸和艾灸对骨质都没有影响。

项目成果

鍼灸刺激は老人性骨粗鬆症の骨強度に影響を与えるか。

针刺刺激会影响老年骨质疏松症的骨强度吗？

• 发表时间: 2014
• 作者: 清水まみ;安田尚史;勝田敦美;中村晃;佐々木弘智;永田正男;原賢太;高橋和真;横野浩一;田野かおり,那須史男
• 通讯作者: 田野かおり,那須史男

鍼灸刺激は老人性骨粗鬆症の骨強度に影響を与えるか

针刺刺激会影响老年骨质疏松症的骨强度吗？

• 发表时间: 2014
• 作者: 清水まみ;安田尚史;中村晃;勝田敦美;佐々木弘智;荒井隆志;永田正男;原賢太;高橋和眞;横野浩一;田野かおり，那須史男
• 通讯作者: 田野かおり，那須史男