Establishment of early diagnosis method for esophageal cancer by mass spectrometry

食管癌质谱早期诊断方法的建立

• 批准号: 23590915
• 负责人: TOYONAGA Takashi
• 金额: $ 3.41万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590915/
• 关键词: 食道がん; 質量分析計; メタボロミクス; 質量分析; メタボローム解析; 早期診断

In this study, we performed metabolome analysis of esophageal cancer patients, and the aim of this study was to discover the biomarkers that are useful for early detection of esophageal cancer. As a result, we found the 17 metabolites that were significantly changed by the pathogenesis of esophageal cancer by metabolome analysis using gas chromatography/mass spectrometry. By lipid metabolome analysis using liquid chromatography/mass spectrometry, we discovered the 47 lipid metabolites with the significant alterations, and by cation/anion metabolome analysis using liquid chromatography/mass spectrometry, we found the 13 metabolites with the significant alterations. These significantly-changed metabolites may be candidates for esophageal cancer biomarkers.

在这项研究中，我们对食道癌患者进行了代谢组学分析，目的是寻找对食道癌早期检测有用的生物标志物。结果，利用气相色谱/质谱仪进行代谢组分析，发现了食道癌发病过程中发生显著变化的17种代谢物。用液相色谱/质谱仪分析脂代谢组，发现有显著变化的47种脂代谢产物；用液相色谱/质谱联用阳/阴离子代谢组分析，发现有13种有显著变化的代谢物。这些明显改变的代谢物可能是食道癌生物标志物的候选对象。

项目成果

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