Role of a novel transcriptional repressor gene, ZFP-BA, in colon cancer proliferation and apoptosis

ZFP-BA是一种新型的转录抑制基因，它与肝素结合的表皮生长因子样生长因子- c末端片段（HB-EGF-CTF）相互作用导致降解，在结肠癌中诱导一些重要的细胞增殖因子，抑制其他细胞凋亡因子。抑制HB-EGF-CTF和ZFP-BA之间的相互作用被认为是必要的，因为可以抑制HB-EGF-CTF易位的药物可能会抑制ZFP-BA的下调。替米沙坦，血管紧张素II型1受体阻断剂（ARBs），是体外HB-EGF-CTF核易位的候选抑制剂之一。然而，结肠癌患者的治疗需要大量的替米沙坦来防止细胞增殖。抑制HB-EGF-CTF核易位信号将构成对抗结直肠癌发展的新策略。ZFP-BA可能成为未来治疗结肠癌策略的靶点之一。

ZFP-BA, a novel transcriptional repressor gene, degradation caused by interaction with the Heparin-binding epidermal growth factor-like growth factor-C-terminal fragment (HB-EGF-CTF) should induce some important factors for cell proliferation and inhibit others for cell apoptosis in colon cancers. The inhibition of interactions between HB-EGF-CTF and ZFP-BA is considered essential because agents that can inhibit HB-EGF-CTF translocation might suppress ZFP-BA downregulation.Telmisartan, angiotensin II type 1 receptor blockers (ARBs), is one of the candidate inhibitors of HB-EGF-CTF nuclear translocation in vitro. However, treatment for humans with colon cancer would require high volume of telmisartan to prevent cell proliferation. The inhibition of HB-EGF-CTF nuclear translocation signaling will comprise a new strategy against the development of colorectal cancer. ZFP-BA might become one of the targets of future strategies to treat colon cancers.