Clinical application of apotosis-inducible factor for inflammatory cells from patients with idiopathic pulmonary fibrosis

特发性肺纤维化炎症细胞凋亡诱导因子的临床应用

• 批准号: 23591153
• 负责人: NUREKI Shin-ichi
• 金额: $ 2.5万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591153/
• 关键词: 特発性肺線維症; 炎症細胞; アポトーシス

RCAS1 levels in the bronchoalveolar lavage fluid (BALF) were significantly higher in patients with idiopathic pulmonary fibrosis (IPF) than in controls. Immunohistochemistry revealed RCAS1 expression in alveolar macrophages, type II alveolar epithelial cells, T-lymphocytes in lymphoid follicle, B-lymphocytes around lymphoid follicles, fibroblast in fibroblastic foci in the lung specimen from patients with IPF. Serum levels of RAS1 in patients with IPF were significantly higher than healthy volunteers. Serum levels of RCAS1 were correlated with the BALF levels of RCAS1. Serum RCAS1 concentrations were correlated with percent predicted forced vital capacity from patients with IPF.

特发性肺纤维化(IPF)患者支气管肺泡灌洗液(BALF)中RCAS1水平明显高于正常对照组。免疫组织化学结果显示，IPF患者肺组织中RCAS1表达于肺泡巨噬细胞、肺泡II型上皮细胞、淋巴滤泡中的T淋巴细胞、淋巴滤泡周围的B淋巴细胞以及成纤维细胞。IPF患者血清RAS1水平明显高于正常对照组。血清RCAS1水平与BALF中RCAS1水平呈正相关。血清RCAS1浓度与IPF患者预测的用力肺活量百分比相关。

项目成果

特発性肺線維症におけるリンパ球アポトーシス誘導因子RCAS1の検討

特发性肺纤维化淋巴细胞凋亡诱导因子RCAS1的检测

• 发表时间: 2013
• 作者: Nakashima T;Yokoyama A;Inata J;Ishikawa N;Haruta Y;Hattori N;Kohno N;横山哲也,濵田直樹,緒方彩子,前山隆茂,鈴木邦裕,三雲大功,猪島一朗,中西洋一;後藤昭彦，濡木真一，その他9名
• 通讯作者: 後藤昭彦，濡木真一，その他9名

特発性肺線維症におけるリンパ球アポトーシス誘導因子の検討

特发性肺纤维化淋巴细胞凋亡诱导因子的检测

• 发表时间: 2013
• 作者: 後藤昭彦;濡木真一;その他12名
• 通讯作者: その他12名