Clinical application of apotosis-inducible factor for inflammatory cells from patients with idiopathic pulmonary fibrosis

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RCAS1 levels in the bronchoalveolar lavage fluid (BALF) were significantly higher in patients with idiopathic pulmonary fibrosis (IPF) than in controls. Immunohistochemistry revealed RCAS1 expression in alveolar macrophages, type II alveolar epithelial cells, T-lymphocytes in lymphoid follicle, B-lymphocytes around lymphoid follicles, fibroblast in fibroblastic foci in the lung specimen from patients with IPF. Serum levels of RAS1 in patients with IPF were significantly higher than healthy volunteers. Serum levels of RCAS1 were correlated with the BALF levels of RCAS1. Serum RCAS1 concentrations were correlated with percent predicted forced vital capacity from patients with IPF.