Basic study of neuroregenerative therapy for diabetic polyneuropathy

为了阐明VEGF基因治疗的神经再生作用，我们研究了STZ糖尿病小鼠的感觉神经病变。我们发现，在这些小鼠的糖尿病早期阶段，有髓纤维的成熟受损和无髓纤维的萎缩同时发生。在坐骨神经中，观察到VEGF信号通路中的基因表达增加和PGE2含量减少。VEGF的逆行转运在小鼠中未被识别。

To elucidate the neuroregenerative effect of VEGF gene therapy, we examined sensory neuropathy in STZ diabetic mice. We found that both impaired maturation of myelinated fibers and atrophy of unmyelinated fibers simultaneously occur in the early stage of diabetes in these mice. In sciatic nerves, increased gene expression in VEGF signaling pathways, and reduction of PGE2 contents were observed. Retrograde transport of VEGF was not recognized in the mice.