The role of senescence marker protein-30 (SMP30) in the progression of diabetic nephropathy

衰老标记蛋白30（SMP30）在糖尿病肾病进展中的作用

• 批准号: 23591317
• 负责人: HASEGAWA Goji
• 金额: $ 3.33万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591317/
• 关键词: 糖尿病; 糖尿病腎症; 尿細管障害; SMP30; 糖尿病合併症; ビタミンC

Senescence marker protein-30 (SMP30) decreases with age and contributes to the symptoms of aging. In this study, we investigated the effect of SMP30 deficiency on the pathogenesis of diabetic nephropathy using streptozocin induced diabetic SMP30 knockout (KO) mice. Tubular damages with tubulointerstitial fibrosis were observed in non-diabetic KO mice, and diabetes exacerbated these changes. On the other hand, SMP30 deletion did not affect glomerular changes. The accumulation of HIF-1alpha, the increase of oxidative stress, and tubular inflammation were associated with tubular injuries. In conclusion, decreased SMP30 with age may contribute to the progression of diabetic nephropathy through tubular damages.

衰老标记蛋白-30（SMP 30）随着年龄的增长而减少，并导致衰老症状。本研究采用链脲佐菌素（STZ）诱导的糖尿病SMP 30基因敲除（KO）小鼠，观察SMP 30缺陷对糖尿病肾病发病机制的影响。在非糖尿病KO小鼠中观察到肾小管损伤伴肾小管间质纤维化，糖尿病加重了这些变化。另一方面，SMP 30缺失不影响肾小球变化。HIF-1 α的积累、氧化应激的增加和肾小管炎症与肾小管损伤相关。总之，随着年龄的增长，SMP 30降低可能通过肾小管损伤促进糖尿病肾病的进展。

项目成果

Insulin Release from Pancreatic Islet in Vitamin C-Deficient Senescence Marker Protein-30/Gluconolactonase Knockout Mice

缺乏维生素 C 的衰老标记蛋白-30/葡萄糖酸内酯酶基因敲除小鼠胰岛的胰岛素释放

• 发表时间: 2011
• 作者: Senmaru T;Hasegawa G;Ishigami A;Kondo Y;Okada H;Asano M;Yamazaki M;Fukui M;Nakamura N
• 通讯作者: Nakamura N

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.

• DOI: 10.3164/jcbn.11-52
• 发表时间: 2012-03
• 期刊: Journal of clinical biochemistry and nutrition
• 影响因子: 2.4
• 作者: Senmaru T;Yamazaki M;Okada H;Asano M;Fukui M;Nakamura N;Obayashi H;Kondo Y;Maruyama N;Ishigami A;Hasegawa G
• 通讯作者: Hasegawa G

Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.

• DOI: 10.1111/jdi.12252
• 发表时间: 2015-01
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Okada H;Senmaru T;Fukui M;Kondo Y;Ishigami A;Maruyama N;Obayashi H;Yamazaki M;Nakamura N;Hasegawa G
• 通讯作者: Hasegawa G

ビタミンＣ欠乏は糖尿病性腎症の尿細管病変の発症に関与する：SMP30 KOマウスを用いての検討．

维生素 C 缺乏与糖尿病肾病肾小管病变的发展有关：使用 SMP30 KO 小鼠进行的研究。

• 发表时间: 2012
• 作者: 岡田博史;千丸貴史;石神昭人;近藤嘉高;尾林博;浅野麻衣;山崎真裕;福井道明;長谷川剛二;中村直登
• 通讯作者: 中村直登

Senescence marker protein-30 deficiency accelerates diabetic renal injury through tubulointerstitial fibrosis in a mouse model of type 1 diabetes.

在 1 型糖尿病小鼠模型中，衰老标记蛋白 30 缺乏会通过肾小管间质纤维化加速糖尿病肾损伤。

• 发表时间: 2013
• 作者: Okada H.;Senmaru T.;Kondo Y.;Ishigami A.;Obayashi H.;Asano M.;Yamazaki M.;Fukui M.;Hasegawa G. and Nakamura N.
• 通讯作者: Hasegawa G. and Nakamura N.