The cytotoxic effect by natural killer cells against pediatric malignant solid tumors

本文分析了NK细胞对小儿实体瘤的杀伤作用及其机制。 神经母细胞瘤细胞系NK抑制性受体配体HLA I类分子的表面表达明显低于其他肿瘤细胞系。 NK活化受体配体在神经母细胞瘤细胞中的表达也较低，而在其他肿瘤细胞中的表达稍高。 我们证实了NK细胞对神经母细胞瘤和恶性横纹肌样瘤的细胞毒性。 而供者NK细胞与靶细胞的HLA-C组配型不匹配对细胞毒作用的影响不明显。

We analyzed the effect and the mechanisms of the cytotoxicity of NK cells against pediatric solid tumors. The surface expressions of HLA class I as ligand of NK inhibitory receptors in neuroblastoma cell lines were significantly lower than ones in the other tumor cell lines. The expressions of the ligands of NK activating receptor were also low in neuroblastoma cells, but slightly high in some other tumor cells. We confirmed the cytotoxicities of NK cells against the neuroblastoma and malignant rhabdoid tumor. However, the effects by the mismatch of HLA-C group between donor NK cells and target tumor cells were not significant in this cytotoxicities.