Cutaneous immunoregulatory functions of a novel antimicrobial agent, catestatin

Catestatin最初被认为是神经内分泌调节剂，是一种在皮肤角质形成细胞和成纤维细胞中发现的抗微生物剂，并且在伤口愈合和感染期间过度表达。在这项研究中，我们观察到Catestatin和新发现的抗菌肽（称为IDR）刺激人角质形成细胞和中性粒细胞的各种功能，导致伤口愈合加速。因此，除了它们的杀微生物特性之外，皮肤来源的抗微生物剂还可能通过激活角质形成细胞参与皮肤宿主防御、炎症和先天免疫系统的调节。

Catestatin, initially believed to act as an neuroendocrine regulator, is an antimicrobial agent found in the skin keratinocytes and fibroblasts, and is over-expressed during wound healing and infection. In this study, we observed that Catestatin and the newly discovered antimicrobial peptides known as IDRs stimulated various functions of human keratinocytes and neutrophils, leading to the wound healing acceleration. Thus, in addition to their microbiocidal properties, skin-derived antimicrobial agents might also participate to the regulation of cutaneous host defense, inflammation and innate immune system through activation of keratinocytes.