Cutaneous immunoregulatory functions of a novel antimicrobial agent, catestatin

新型抗菌剂儿茶素的皮肤免疫调节功能

• 批准号: 23591655
• 负责人: NIYONSABA FRANCOIS
• 金额: $ 3.24万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591655/
• 关键词: 抗菌ペプチド; 皮膚免疫; 自然免疫; ケラチノサイト; 好中球; 抗菌物質; マスト細胞

Catestatin, initially believed to act as an neuroendocrine regulator, is an antimicrobial agent found in the skin keratinocytes and fibroblasts, and is over-expressed during wound healing and infection. In this study, we observed that Catestatin and the newly discovered antimicrobial peptides known as IDRs stimulated various functions of human keratinocytes and neutrophils, leading to the wound healing acceleration. Thus, in addition to their microbiocidal properties, skin-derived antimicrobial agents might also participate to the regulation of cutaneous host defense, inflammation and innate immune system through activation of keratinocytes.

Catestatin最初被认为是一种神经内分泌调节剂，是一种存在于皮肤角质形成细胞和成纤维细胞中的抗菌剂，在伤口愈合和感染期间过度表达。在这项研究中，我们观察到Catestatin和新发现的抗菌肽（称为IDR）刺激人角质形成细胞和中性粒细胞的各种功能，导致伤口愈合加速。因此，除了它们的杀微生物特性之外，皮肤来源的抗微生物剂还可能通过激活角质形成细胞参与皮肤宿主防御、炎症和先天免疫系统的调节。

项目成果

Human b-defensin-3 improves the epithelial tight junction (TJ) barrier through activation of glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC)

人 b-防御素-3 通过激活糖原合酶激酶 3 (GSK-3) 和蛋白激酶 C (PKC) 改善上皮紧密连接 (TJ) 屏障

• 发表时间: 2013
• 作者: Kiatsurayanon C;Niyonsaba F et al.
• 通讯作者: Niyonsaba F et al.

Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes

• DOI: 10.1016/j.jdermsci.2011.08.001
• 发表时间: 2011-11-01
• 期刊: JOURNAL OF DERMATOLOGICAL SCIENCE
• 影响因子: 4.6
• 作者: Hoq, Md Imranul;Niyonsaba, Francois;Ogawa, Hideoki
• 通讯作者: Ogawa, Hideoki

Modulation of neutrophil apoptosis by antimicrobial peptides.

• DOI: 10.5402/2012/345791
• 发表时间: 2012
• 期刊: ISRN microbiology
• 作者: Nagaoka I;Suzuki K;Niyonsaba F;Tamura H;Hirata M
• 通讯作者: Hirata M

Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions

合成免疫调节肽 IDR-HH2、IDR-1002 和 IDR-1018 调节中性粒细胞功能

• 发表时间: 2013
• 作者: Niyonsaba F;Madera L;Okumura K;Ogawa H;Hancock REW
• 通讯作者: Hancock REW

Effects of human β-defensins on interleukin-37 production by human keratinocytes

人 β-防御素对人角质形成细胞产生白细胞介素 37 的影响

• 发表时间: 2013
• 作者: SmithritheeR;Niyonsaba F et al.
• 通讯作者: Niyonsaba F et al.