Cutaneous immunoregulatory functions of a novel antimicrobial agent, catestatin

儿茶素最初被认为是一种神经内分泌调节因子，是一种在皮肤角质形成细胞和成纤维细胞中发现的抗菌剂，在伤口愈合和感染过程中过度表达。在本研究中，我们观察到儿茶素和新发现的抗菌肽IDRs刺激人角质形成细胞和中性粒细胞的各种功能，导致伤口加速愈合。因此，皮肤来源的抗菌剂除了具有杀菌作用外，还可能通过激活角质形成细胞参与调节皮肤宿主防御、炎症和先天免疫系统。

Catestatin, initially believed to act as an neuroendocrine regulator, is an antimicrobial agent found in the skin keratinocytes and fibroblasts, and is over-expressed during wound healing and infection. In this study, we observed that Catestatin and the newly discovered antimicrobial peptides known as IDRs stimulated various functions of human keratinocytes and neutrophils, leading to the wound healing acceleration. Thus, in addition to their microbiocidal properties, skin-derived antimicrobial agents might also participate to the regulation of cutaneous host defense, inflammation and innate immune system through activation of keratinocytes.