Stem cell therapy for psychiatric disorders using granulocyte-colony stimulating factor

使用粒细胞集落刺激因子干细胞治疗精神疾病

• 批准号: 23591678
• 负责人: YOSHINAGA TOSHIHIRO
• 金额: $ 3.33万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591678/
• 关键词: 精神薬理学; 顆粒球コロニー刺激因子; 細胞治療; 再生医療; 神経幹細胞; 神経新生; 造血幹細胞移植; G-CSF; 造血幹細胞; 胎児性アルコールスペクトラム障害; 骨髄移植; 精神薬理; 胎児性アルコールスペクトラム症候群

The purpose of this study is to develop a possible therapeutic approach for psychiatric disorders by neurogenesis upregulation through increase of peripheral hematopoietic stem cells. First, we have demonstrated that the combined peripheral treatment of stem cells and antidepressant, which has been indicated to increase trophic factors in the serum could have potential to recover the abnormal behavior of treatment-resistant refractory depression model. We have also shown that peripherally treated neural stem cells concentrated much in the hypothalamus areas where oxytocin/vasopresinergic neurons exist, and recovered social/cognitive impairment of psychiatric disease model including parental behavior.

本研究的目的是通过增加外周造血干细胞来上调神经发生，从而为精神疾病的治疗提供一种可能的途径。首先，我们已经证明，干细胞和抗抑郁药的联合外周治疗（已表明可增加血清中的营养因子）可能具有恢复难治性抑郁模型异常行为的潜力。我们还表明，外周处理的神经干细胞集中在下丘脑区域，催产素/血管加压素能神经元存在，并恢复社会/认知障碍的精神疾病模型，包括父母的行为。

项目成果

Stem cell therapy: a new approach to the treatment of refractory depression.

• DOI: 10.1007/s00702-014-1194-2
• 发表时间: 2014-10
• 期刊: JOURNAL OF NEURAL TRANSMISSION
• 影响因子: 3.3
• 作者: Kigawa, Yoshiyasu;Hashimoto, Eri;Ukai, Wataru;Ishii, Takao;Furuse, Kengo;Tsujino, Hanako;Shirasaka, Tomohiro;Saito, Toshikazu
• 通讯作者: Saito, Toshikazu

Stem cell research on Alcoholism. [Symposium] Biomedical Approach on Alcoholism

酒精中毒的干细胞研究。

• 发表时间: 2013
• 作者: Ukai W;Hashimoto E;Ishii T;Kigawa Y;Yoshinaga T ;Watanabe K;Shirasaka T;Tateno M;Kobayashi S;Saito T
• 通讯作者: Saito T

精神疾患に対する再生医療的アプローチの可能性．

再生医学方法治疗精神疾病的可能性。

• 发表时间: 2013
• 作者: 宮田久嗣;石井 洵平;鵜飼渉，橋本恵理，石井貴男，木川昌康，古瀬健吾，辻野華子，白坂知彦，吉永敏弘，小林清樹，齋藤利和．
• 通讯作者: 鵜飼渉，橋本恵理，石井貴男，木川昌康，古瀬健吾，辻野華子，白坂知彦，吉永敏弘，小林清樹，齋藤利和．

Stem cell therapy: social recognition recovery in a FASD model.

• DOI: 10.1038/tp.2012.111
• 发表时间: 2012-11-13
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Shirasaka T;Hashimoto E;Ukai W;Yoshinaga T;Ishii T;Tateno M;Saito T
• 通讯作者: Saito T

Usage of peripheral-derived cytokine as a marker and treatment approach for neural plasticity change in alcohol-induced brain damage and depression, Translational perspective on the imaging, epigenetics and peripheral-derived markers for alcohol induced b

使用外周源性细胞因子作为酒精性脑损伤和抑郁症神经可塑性变化的标记物和治疗方法，酒精性脑损伤和抑郁症的成像、表观遗传学和外周源性标记物的转化视角

• 发表时间: 2013
• 作者: Hashimoto E;Ukai W;Ishii T;Watanabe K;Shirasaka T;Kaneta H;Kigawa Y;Yoshinaga T;Tateno M;Saito T
• 通讯作者: Saito T