Synthesis of novel copper-labeled agents for PET imaging as an alternative to technetium radiopharmaceuticals

用于 PET 成像的新型铜标记试剂的合成，作为锝放射性药物的替代品

• 批准号: 23591829
• 负责人: SUGO Yumi
• 金额: $ 3.16万
• 依托单位: Japan Atomic Energy Agency
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591829/
• 关键词: 放射性同位元素; ポジトロン; Cu-64; ペプチド; 分子プローブ; 環状ペプチド

Technetium-99m (Tc-99m) is most commonly used as diagnostic radiopharmaceuticals. Tc-99m is generated by decay of molybdenum-99 (Mo-99), of which supply depends fully on the import from foreign countries. Recently, the supply shortage is the serious problem in the hospital.Copper-64 (Cu-64) is a useful radionuclide in nuclear medicine, and can be produced by the cyclotron using (p,n) nuclear reaction from nickel-64 (Ni-64). In this study, we designed and synthesized some novel Cu-64 labeled agents for positron emission tomography (PET) imaging as an alternative to the Tc-99m radiopharmaceuticals.

锝-99m（Tc-99 m）是最常用的诊断放射性药物。Tc-99 m是由Mo-99衰变产生的，其供应完全依赖于从国外进口。铜-64（Cu-64）是核医学中一种重要的放射性核素，它是由镍-64（Ni-64）通过（p，n）核反应在回旋加速器上产生的。在这项研究中，我们设计和合成了一些新的Cu-64标记剂的正电子发射断层扫描（PET）成像作为替代的Tc-99 m放射性药物。