Synthesis of novel copper-labeled agents for PET imaging as an alternative to technetium radiopharmaceuticals

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Technetium-99m (Tc-99m) is most commonly used as diagnostic radiopharmaceuticals. Tc-99m is generated by decay of molybdenum-99 (Mo-99), of which supply depends fully on the import from foreign countries. Recently, the supply shortage is the serious problem in the hospital.Copper-64 (Cu-64) is a useful radionuclide in nuclear medicine, and can be produced by the cyclotron using (p,n) nuclear reaction from nickel-64 (Ni-64). In this study, we designed and synthesized some novel Cu-64 labeled agents for positron emission tomography (PET) imaging as an alternative to the Tc-99m radiopharmaceuticals.