Proteomic analysis for RTK regulation by nitric oxide and its application to cancer therapy
Proteomic analysis for RTK regulation by nitric oxide and its application to cancer therapy
一氧化氮RTK调节的蛋白质组学分析及其在癌症治疗中的应用
批准号：
23592016
负责人：
SUGITA Hiroki
金额：
$3.33万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
中文摘要
翻译
为了阐明一氧化氮对胰岛素样生长因子（insulin-like growth factor，IGF）信号转导的调控机制，我们采用酵母双杂交技术，寻找与胰岛素受体底物（insulin receptor substrate，IRS）-1结合的蛋白质。进行cDNA文库的筛选。筛选出8个蛋白质作为IRS-I的候选调控因子。我们发现其中一个与IRS-1结合并调节IGF信号传导。
英文摘要
To clarify the mechanisms of insulin-like growth factor(IGF) signaling regulated by nitric oxide, we performed Yeast Two Hybrid Assay which can search a protein binding to insulin receptor substrate( IRS)-1. Screening for cDNA library was performed. Eight proteins were selected as candidate of regulator of IRS-I. We found out that one of them bind to IRS-1 and regulated IGF signaling.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI：
10.1002/ijc.28672
发表时间：
2014-12-01
期刊：
INTERNATIONAL JOURNAL OF CANCER
影响因子：
6.4
作者：
[Ishikawa, S., Hayashi, H., Kinoshita, K., Abe, M., Kuroki, H., Tokunaga, R., Tomiyasu, S., Tanaka, H., Sugita, H., Arita, T., Yagi, Y., Watanabe, M., Hirota, M., Baba, H.]
通讯作者：
Baba, H.
Proteomic analysis of the regulation of proteins by NO-induced posttranslational modification and anti-cancer therapy
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批准号：20591633
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$3.0万
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财政年份：2008
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负责人：SUGITA Hiroki
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依托单位：
The analysis of molecular mechanism for IRS-1 ubiquitination by nitric oxide
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批准号：18591517
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.53万
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财政年份：2006
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负责人：SUGITA Hiroki
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依托单位：
海外基金
