Prevention of Vascular Restenosis After Vascular Angioplasty by Endothelial specific BNCT

内皮特异性 BNCT 预防血管成形术后血管再狭窄

• 批准号: 23592084
• 负责人: NAKAI Kei
• 金额: $ 3.33万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592084/
• 关键词: 脳血管内外科学; ホウ素中性子捕捉療法; リポソーム; ホウ素送達システム; 血管内皮; 血管形成術; 再狭窄

We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron containing liposome. The liposome is expected that have EPR effect and adhesive property by sizing and surface modification. Cells were cultured with B containing medium, and neutron irradiation revealed the radiobiological effect of boron neutron capture. borocaptate sodium solution was encapsulated in this liposome, then it achieves the 2.5 times higher boron concentration than nano-particle only.

我们的目的是通过开发一种新的药物输送系统，以确保足够浓度的（10）B的硼中子俘获治疗（BNCT）。我们设计并开发了一种新型的脂质类似物，并成功地将其用于新型含硼脂质体的研制。通过对脂质体进行上浆和表面改性，有望使脂质体具有EPR效应和粘附性。用含B的培养基培养细胞，中子照射揭示了硼中子俘获的放射生物学效应。将硼癸酸钠溶液包封在该脂质体中，则其达到比仅纳米颗粒高2.5倍的硼浓度。