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Research the regulators, including cytokine, of intratumoral biosynthesis of estrogen in endometrial cancer microenvironment

Research the regulators, including cytokine, of intratumoral biosynthesis of estrogen in endometrial cancer microenvironment
研究子宫内膜癌微环境中雌激素瘤内生物合成的调节因子,包括细胞因子
批准号:
23592431
负责人:
ITO Kiyoshi
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Intratumoral concentrations of sex-steroid hormone and stress hormone wereelevated in the endometrial carcinoma. On the other hand, we indicated steroid sulfatase played a veryimportant role in the local biosynthesis of estrogen in human endometrial cancer through tumor-stromal cell interactions. Therefore, steroid sulfatase inhibitors should be useful drugs especially for patients with endometrial cancers, which have steroid sulfatase activities.
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DOI: 10.1002/ijc.27345
发表时间: 2012-08-15
期刊: INTERNATIONAL JOURNAL OF CANCER
影响因子: 6.4
作者: [Hiroki, Eri, Suzuki, Fumihiko, Yaegashi, Nobuo]
通讯作者: Yaegashi, Nobuo
子宮癌肉腫における術前内膜細胞診の意義
子宫癌肉瘤术前子宫内膜细胞学检查的意义
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [志賀尚美, 岡本聡, 海法道子, 宇都宮裕貴, 永瀬智, 高野忠夫, 新倉仁, 伊藤潔, 八重樫伸生]
通讯作者: 八重樫伸生
Multidisciplinary approach to a case of Lynch syndrome with colorectal, ovarian, and metastatic liver carcinomas
多学科方法治疗林奇综合征合并结直肠癌、卵巢癌和转移性肝癌一例
DOI: --
发表时间: 2012
期刊: Int Canc Conf J
影响因子: --
作者: [Shiono M, Shimodaira H, Watanabe M, Takase K, Ito K, Miura K, Takami Y, Akiyama S, Kakudo Y, Takahashi S, Takahashi M, Ishioka C]
通讯作者: Ishioka C
ヒト子宮内膜癌におけるCRH発現と予後の関連
人子宫内膜癌CRH表达与预后的关系
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [佐藤菜保子, 高木清司, 鈴木貴, 三木康宏, 割田仁, 福土審, 佐藤冨美子八重樫伸生, 伊藤潔]
通讯作者: 伊藤潔
52
    Role and regulation of sex steroid synthesis key enzyme:CYP17 in endometrial cancer
    • 批准号:
      17K11266
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2017
    • 负责人:
      ITO Kiyoshi
    • 依托单位:
    Structural analyses of the high molecular mass peptidases belonging to M1 and S9 families
    Metabolic syndrome and endometrial cancer-PPARγ ligands as useful drug candidates for endocrine treatment-
    • 批准号:
      19591921
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2007
    • 负责人:
      ITO Kiyoshi
    • 依托单位:
    Protein engineering of the enzymes for clinical analysis based on their three dimensional structures
    • 批准号:
      19570108
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2007
    • 负责人:
      ITO Kiyoshi
    • 依托单位:
    海外基金