Research the regulators, including cytokine, of intratumoral biosynthesis of estrogen in endometrial cancer microenvironment

研究子宫内膜癌微环境中雌激素瘤内生物合成的调节因子，包括细胞因子

• 批准号: 23592431
• 负责人: ITO Kiyoshi
• 金额: $ 3.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592431/
• 关键词: 癌―間質相互作用; 子宮内膜癌; intracrinology; estrogen; testosterone; steroid sulfatase; 子宮内膜異型増殖症; LC-MS/MS法; Intracrinology; Estrogen; Testosterone; 5α-dihydrotestosterone; CRH; Androstenedione

Intratumoral concentrations of sex-steroid hormone and stress hormone wereelevated in the endometrial carcinoma. On the other hand, we indicated steroid sulfatase played a veryimportant role in the local biosynthesis of estrogen in human endometrial cancer through tumor-stromal cell interactions. Therefore, steroid sulfatase inhibitors should be useful drugs especially for patients with endometrial cancers, which have steroid sulfatase activities.

子宫内膜癌瘤内性类固醇激素和应激激素浓度升高。另一方面，我们发现类固醇硫酸酯酶通过肿瘤-间质细胞的相互作用在子宫内膜癌局部雌激素的生物合成中起着非常重要的作用。因此，类固醇硫酸酯酶抑制剂尤其适用于具有类固醇硫酸酯酶活性的子宫内膜癌患者。

项目成果

MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma

• DOI: 10.1002/ijc.27345
• 发表时间: 2012-08-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Hiroki, Eri;Suzuki, Fumihiko;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo

子宮癌肉腫における術前内膜細胞診の意義

子宫癌肉瘤术前子宫内膜细胞学检查的意义

• 发表时间: 2014
• 作者: 志賀尚美;岡本聡;海法道子;宇都宮裕貴;永瀬智;高野忠夫;新倉仁;伊藤潔;八重樫伸生
• 通讯作者: 八重樫伸生

Multidisciplinary approach to a case of Lynch syndrome with colorectal, ovarian, and metastatic liver carcinomas

多学科方法治疗林奇综合征合并结直肠癌、卵巢癌和转移性肝癌一例

• 发表时间: 2012
• 期刊: Int Canc Conf J
• 作者: Shiono M;Shimodaira H;Watanabe M;Takase K;Ito K;Miura K;Takami Y;Akiyama S;Kakudo Y;Takahashi S;Takahashi M;Ishioka C
• 通讯作者: Ishioka C

ヒト子宮内膜癌におけるCRH発現と予後の関連

人子宫内膜癌CRH表达与预后的关系

• 发表时间: 2013
• 作者: 佐藤菜保子;高木清司;鈴木貴;三木康宏;割田仁;福土審;佐藤冨美子八重樫伸生;伊藤潔
• 通讯作者: 伊藤潔

Feasibility study of gemcitabine plus docetaxel in advanced or recurrent uterine leiomyosarcoma and undifferentiated endometrial sarcoma in Japan

• DOI: 10.1007/s10147-013-0627-5
• 发表时间: 2014-10-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Takano, Tadao;Niikura, Hitoshi;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo