The study of the gene distribution and the role in hard tissue formation of amelogenin

牙釉蛋白基因分布及其在硬组织形成中作用的研究

• 批准号: 23592807
• 负责人: YAMADA Yoshishige
• 金额: $ 3.41万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592807/
• 关键词: アメロジェニン; マウス胎仔; エクソン; In situ hybridization法; in situ hybridization法; パラフィン切片; in situ PCR; in situ LAMP; in situ hybridizatiom; 胎生マウス; マウス胎児; PCR法; in situ PCR法; LAMP法

According to the results of in situ hybridization, amelogenin gene expression was observed several non tooth related tissue such as brain, kidney, eye and bone related tissues.The amelogenin gene expression in these tissues, were a significant small amount of gene expression compared with gene expression in ameloblast of incisor. The tendency of the expression level of the amelogenin gene in the tissue they become strong in the late gestation than early fetal period has been confirmed.

原位杂交结果显示，釉原蛋白基因在非牙源性组织如脑、肾、眼和骨组织中均有表达，与切牙成釉细胞相比，有少量表达。釉原蛋白基因在组织中的表达水平在妊娠晚期比胎儿早期增强的趋势已被证实。

项目成果

胎生マウスにおけるアメロジェニン遺伝子発現様式の検討

胚胎小鼠牙釉蛋白基因表达模式的检查

• 发表时间: 2013
• 作者: 竹中彰治;若松里佳;大墨竜也; 福田敬;富田文仁;興地隆史;山田嘉重
• 通讯作者: 山田嘉重