Study of pharmacological action and the adverse effect of the local anesthetic from a new viewpoint

局部麻醉剂被认为通过抑制神经元钠通道而产生麻醉作用，但这种抑制不能解释局部麻醉剂的所有作用和各种不良反应。大鼠脑内存在多种Ca-和Mg-ATPase，但在本研究中，局麻药抑制了在碱性pH下工作的Ca-Mg-ATPase的活性。麻醉作用强的局麻药对Na，K-ATPase活性有较强的抑制作用。这些ATPase可能与局部麻醉剂的作用有关。

Local anesthetics are supposed to produce anesthetic action by inhibiting a neuronal sodium channel, but this inhibition cannot explain all the effects of the local anesthetic and various kinds of adverse effect. Several kinds of Ca - and Mg-ATPase were present in rat brain, but in this study, the local anesthetic inhibited Ca - Mg-ATPase activity that work in alkaline pH. Also, local anesthetic with strong anesthetic effects strongly inhibited Na,K-ATPase activity. These ATPases may be associated with effects of the local anesthetic.