Reproduction and the function reconstruction of the nucleus tractus spinalis sensory nerve cell in region of face cancer pain and the neuropathic pain

通过对顽固性疼痛的临床状况机制的阐明和神经营养因子的指导，为治疗的临床应用提供一个基本的发现。因此，通过阐明脊髓神经胶质细胞对神经性疼痛和癌性疼痛的相互作用，我们获得了神经营养因子指导治疗的初步发现。发现突触后细胞中的NNDA受体对代数抑制的抑制作用和NO的产生对神经性疼痛有抑制作用。在皮下注射模型中观察到眼下颊区癌细胞的自发性疼痛和厌食性疼痛，但通过给药腺苷再摄取抑制剂可减轻自发性疼痛和厌食性疼痛

We tested it for the purpose of obtaining a basic finding for clinical application of the treatment by elucidation and neurotrophy factor instruction of the clinical condition mechanism of the intractable pain. As a result, by elucidation of the interaction of glia cells of the spinal nerre for neuropathic pain and cancer pain, we obtained the initial finding of the therapy by the neurotrophy factor instruction. Efficacy of the suppression of inhibition and the NO production of the NNDA receptor which was present in postsynaptic cells for algetic suppression was found for the neuropathic pain. Observed spontaneous pain and anorexia in the subcutaneous injection model of the eyes lower buccal region of the cancer cell for cancer pain, but is reduction and anorexia of the spontaneous pain by administration of adenosine reuptake inhibitor