Reproduction and the function reconstruction of the nucleus tractus spinalis sensory nerve cell in region of face cancer pain and the neuropathic pain

面癌痛及神经病理性疼痛区域棘束核感觉神经细胞的再生及功能重建

• 批准号: 23592996
• 负责人: NAKANISHI Osamu
• 金额: $ 3.16万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592996/
• 关键词: 癌性疼痛; 神経障害性疼痛; グリア; 細胞再生; NOS; propentofylline; 神経因性疼痛; 神経栄養因子

We tested it for the purpose of obtaining a basic finding for clinical application of the treatment by elucidation and neurotrophy factor instruction of the clinical condition mechanism of the intractable pain. As a result, by elucidation of the interaction of glia cells of the spinal nerre for neuropathic pain and cancer pain, we obtained the initial finding of the therapy by the neurotrophy factor instruction. Efficacy of the suppression of inhibition and the NO production of the NNDA receptor which was present in postsynaptic cells for algetic suppression was found for the neuropathic pain. Observed spontaneous pain and anorexia in the subcutaneous injection model of the eyes lower buccal region of the cancer cell for cancer pain, but is reduction and anorexia of the spontaneous pain by administration of adenosine reuptake inhibitor

通过对顽固性疼痛的临床状况机制的阐明和神经营养因子的指导，为治疗的临床应用提供一个基本的发现。因此，通过阐明脊髓神经胶质细胞对神经性疼痛和癌性疼痛的相互作用，我们获得了神经营养因子指导治疗的初步发现。发现突触后细胞中的NNDA受体对代数抑制的抑制作用和NO的产生对神经性疼痛有抑制作用。在皮下注射模型中观察到眼下颊区癌细胞的自发性疼痛和厌食性疼痛，但通过给药腺苷再摄取抑制剂可减轻自发性疼痛和厌食性疼痛

项目成果

CENTRAL GLIAL ACTIVATION MEDIATES CANCER-INDUCED PAIN IN A RAT FACIAL CANCER MODEL

• DOI: 10.1016/j.neuroscience.2011.02.007
• 发表时间: 2011-04-28
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Hidaka, K.;Ono, K.;Inenaga, K.
• 通讯作者: Inenaga, K.

4-Methylcatechol(4-MC),BDNF inducer, ameliorates Choronic Pain with Depression via. Prevention of trkB related Signaling

4-甲基儿茶酚 (4-MC)，BDNF 诱导剂，通过缓解抑郁症引起的慢性慢性疼痛。

• 发表时间: 2013
• 作者: Nakanishi O;Ishikawa T
• 通讯作者: Ishikawa T

Neuronal effects of neurokinin B on the rat subfornical organ

神经激肽B对大鼠穹窿下器官的神经元作用

• DOI: 10.1097/wnr.0b013e3283469645
• 发表时间: 2011
• 期刊: Neuroreport
• 影响因子: 1.7
• 作者: Ono K;Asami R;Miyahara N;Nakanishi O;Inenaga K.
• 通讯作者: Inenaga K.

Can the neurovascular compression volume of the trigeminal nerve on magnetic resonance cisternography predict the success of local anesthetic block after initial treatment by the carbamazepine?

磁共振脑池造影三叉神经的神经血管受压体积能否预测卡马西平初始治疗后局麻药阻滞的成功？

• 发表时间: 2012
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol.
• 作者: Shiiba S;Tanaka T;Ono K,Matsumoto-Takeda S;Seta Y; Nakanishi O;Inenaga K;Morimoto Y.
• 通讯作者: Morimoto Y.

A rat pain model of facial cancer.

• DOI: 10.1007/978-1-61779-561-9_10
• 发表时间: 2012
• 期刊: Methods in molecular biology
• 作者: K. Ono;N. Harano;K. Inenaga;O. Nakanishi