NMR Spectroscopy of Complex Cellular Processes

复杂细胞过程的核磁共振波谱分析

• 批准号: DP0345961
• 负责人: Em/Prof Philip Kuchel
• 金额: $ 48.09万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-11-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345961
• 关键词: NMR; Spectroscopy; Complex; Cellular; Processes

The Theme is the cell viewed as a complex regulated molecular assembly. The Aim is to establish an integrated mathematical model of red cell metabolism, membrane transport, shape, and mechanical properties, principally by using NMR spectroscopy. The Significance will be discovery of new aspects of cellular structure and function, and new NMR theory for molecular bioscience. Outcomes will include new NMR measurements of kinetics of metabolic reactions, rates of membrane transport, solute diffusion, and functions of key membrane- and cytoskeletal proteins. Practical applications will include strategies for modelling complex biochemical systems, and circumventing metabolic defects arising from inheritance, the environment, and therapies.

主题是细胞被视为一个复杂的调节分子组装。目的是建立一个完整的数学模型的红细胞代谢，膜运输，形状和机械性能，主要是通过使用NMR光谱。其意义将是发现细胞结构和功能的新方面，以及分子生物科学的新NMR理论。结果将包括新的NMR测量代谢反应的动力学，膜运输率，溶质扩散和关键膜和细胞骨架蛋白的功能。实际应用将包括模拟复杂生化系统的策略，以及规避遗传，环境和治疗引起的代谢缺陷。