A new preventive way on diseases using electronic chaperones as a novel concept

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Our previous report showed that mild electrical stress (MES)enhanced the insulin-induced signaling pathway. However, the molecular mechanism of theeffect of MES remains unclear. We assessed the effect of MES, which is characterized bylow-intensity direct current, on insulin signaling in vitro and in vivo. Here we showedthat MES activated the insulin signaling in an insulin-independent manner, and improvedinsulin resistance in peripheral tissues of high fat-fed mice. Moreover, we found thatMES increased the localization of IR in lipid rafts and enhanced the level ofphosphorylated Akt in insulin-resistant hepatic cells. Ablation of lipid rafts disruptedthe effect of MES on Akt activation