A new preventive way on diseases using electronic chaperones as a novel concept
A new preventive way on diseases using electronic chaperones as a novel concept
批准号:
23650269
负责人:
KAI Hirofumi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Our previous report showed that mild electrical stress (MES)enhanced the insulin-induced signaling pathway. However, the molecular mechanism of theeffect of MES remains unclear. We assessed the effect of MES, which is characterized bylow-intensity direct current, on insulin signaling in vitro and in vivo. Here we showedthat MES activated the insulin signaling in an insulin-independent manner, and improvedinsulin resistance in peripheral tissues of high fat-fed mice. Moreover, we found thatMES increased the localization of IR in lipid rafts and enhanced the level ofphosphorylated Akt in insulin-resistant hepatic cells. Ablation of lipid rafts disruptedthe effect of MES on Akt activation
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Physical Medicine を 科学する~新たな医療機器の研究開発~
物理医学科学~新医疗器械的研究与开发~
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Hoshino M, Uesugi K, Yagi N, Mohri S, Regini J, Pierscionek B., 甲斐 広文]
通讯作者:
甲斐 広文
Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome.
轻度电刺激和热休克可改善阿尔波特综合征小鼠模型中进行性蛋白尿和肾脏炎症。
DOI:
10.1371/journal.pone.0043852
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Koga T, Kai Y, Fukuda R, Morino-Koga S, Suico MA, Koyama K, Sato T, Shuto T, Kai H]
通讯作者:
Kai H
ストレス耐性付与および脂肪蓄積抑制作用を有する新たなphysical medicine
抗压、抑制脂肪堆积的新物理药物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[松山 真吾, 矢野 脩一郎, 古賀(森野) 佐緒里, 島内 裕一郎, 岡本 友加, 四反田 伊穂李, メリーアン スイコ, 首藤 剛, 甲斐 広文]
通讯作者:
甲斐 広文
Physical Medicine を科学する~新たな医療機器の研究開発~
物理医学科学~新医疗器械的研究与开发~
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[筒井ひろみ, 谷下一夫, 松山 真吾, 甲斐 友佳理, 谷下一夫, 甲斐 広文]
通讯作者:
甲斐 広文
微弱パルス電流のLKB1-AMPK経路活性化を介したストレス耐性付与および脂肪蓄積抑制効果
弱脉冲电流通过激活 LKB1-AMPK 通路对应激耐受和脂肪积累抑制的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[奥田聡, 正林康宏, 立嶋智, 谷下一夫, 松山 真吾]
通讯作者:
松山 真吾
共 23 条
Drug development on protein misfolding diseases
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批准号:22390015
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.4万
-
财政年份:2010
-
负责人:KAI Hirofumi
-
依托单位:
Therapeutic principles on protein misfolding diseases
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批准号:19390045
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:KAI Hirofumi
-
依托单位:
Development of therapeutic ways targeting molecular chaperones and ets transcription factors
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批准号:14370748
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:2002
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负责人:KAI Hirofumi
-
依托单位:
MEF plays a role in the pathogenesis of alveolar proteinosis.
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批准号:11672174
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:KAI Hirofumi
-
依托单位:
Novel transcription factor to regulate differentiation of tracheal epithelial cells.
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批准号:09672239
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1997
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负责人:KAI Hirofumi
-
依托单位:
海外基金