Development of therapeutic ways targeting molecular chaperones and ets transcription factors

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1.CFTR was exported from the ER to cis-Golgi and early endosome, suggesting that CFTR transport in the early secretory pathway may utilize a non-conventional pathway. This CFTR trafficking pathway may be a target for pharmacological modulation that selectively stimulates CFTR transport.2.Curcumin may have an unique effect as an accelerator of CFTR trafficking by decreasing calreticulin, a negative regulator of CFTR and have important implications in developing therapeutic approaches that target the trafficking of CFTR.3.The recruitment of MEF to PML nuclear bodies regulates lysozyme transcription in epithelial cells.4.MEF may play an important role in regulating HBD2 expression in epithelial cells.5.MEF is a tumor suppressor gene on the X chromosome with activities that are opposite to those of ETS-2.6.PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression.