The role of DNA damage induced chromatin dynamics in the establishment and maintenance of pluripotency of stem cells

我们以前已经证明，Tip60组蛋白乙酰转移酶复合体调节组蛋白H_2AX在DNA损伤时的驱逐，从而促进DNA损伤反应信号转导。在这项研究中，我们测试了由Tip60调控的染色质动力学是否参与了包括iPS细胞在内的干细胞多能性的建立或维持。因此，我们发现Tip60不参与iPS细胞多能性的建立。

We have previously shown that TIP60 histone acetyltransferase complex regulates histone H2AX eviction upon DNA damage, which facilitate DNA damage response signaling. In this study, we tested whether chromatin dynamics via H2AX regulated by TIP60 is involved in the establishment or maintenance of pluripotency of stem cells including iPS cells. As a result, we found that TIP60 is not involved in the establishment of pluripotency of iPS cells.