New Strategies and Catalysts for an Economic Access to Highly Functional Asymmetric Macrocycles

该项目的目的是设计和阐述快速，高效和最小化浪费的策略和工具，用于合成分子量范围在500到2000之间的不对称，高度功能化的大环。多达八个建筑模块将以一锅的方式组合和循环。整个过程包括构建模块的合成将不包括单个碳的损失，理想情况下只有水或在酶应用的情况下释放各自的活化基团（例如二磷酸）。即使设计的化学催化剂也应该是可回收的，因为固定化，和/或不含金属。这将通过天然产物衍生的双官能或多官能构建块、多或多联锁的多组分反应（最初主要是ugi型反应）、新的环化过程（通过多组分和酶催化的环化反应）、多组分反应的新催化体系的研究以及上述所有这些的组合来实现。

The aim of the project is the design and elaboration of rapid, efficient and waste-minimized strategies and tools for the synthesis of asymmetric, highly functionalized macrocycles of a molecular weight range of ca. 500 to 2000. Up to eight building blocks will be combined and cyclized in a one pot fashion. The overall process including the synthesis of the building blocks will not include the loss of a single carbon, ideally only water or in the case of enzyme applications the respective activation groups (e.g. diphosphate) are released. Even the designed chemical catalysts should either be recoverable due to immobilization, and/or be metal free. This will be achieved by natural product derived di- or polyfunctional building blocks, multiple or multiple-interlocked multi-component reactions -initially mostly of UGI-type-, new cyclization processes (by multi-component and enzyme-catalyzed cyclization reactions), the study of new catalytic systems for multi-component-reactions and combinations of all of the above.