New Strategies and Catalysts for an Economic Access to Highly Functional Asymmetric Macrocycles

经济获取高功能不对称大环化合物的新策略和催化剂

• 批准号: 5407883
• 负责人: Professor Dr. Ludger A. Wessjohann
• 金额: --
• 依托单位: Abteilung Natur- und Wirkstoffchemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5407883?language=en
• 关键词: New; Strategies; Catalysts; Economic; Access

The aim of the project is the design and elaboration of rapid, efficient and waste-minimized strategies and tools for the synthesis of asymmetric, highly functionalized macrocycles of a molecular weight range of ca. 500 to 2000. Up to eight building blocks will be combined and cyclized in a one pot fashion. The overall process including the synthesis of the building blocks will not include the loss of a single carbon, ideally only water or in the case of enzyme applications the respective activation groups (e.g. diphosphate) are released. Even the designed chemical catalysts should either be recoverable due to immobilization, and/or be metal free. This will be achieved by natural product derived di- or polyfunctional building blocks, multiple or multiple-interlocked multi-component reactions -initially mostly of UGI-type-, new cyclization processes (by multi-component and enzyme-catalyzed cyclization reactions), the study of new catalytic systems for multi-component-reactions and combinations of all of the above.

该项目的目的是设计和阐述快速，高效和浪费的策略和工具，用于合成Ca的分子量范围的不对称，高度功能化的大环。 500至2000年。将以一种锅的方式将多达八个构建块组合在一起。包括构建块的合成在内的总体过程将不包括单个碳的损失，理想情况下仅是水或在酶应用的情况下，各自的激活组（例如二磷酸）都会释放出来。即使是设计的化学催化剂也应由于固定而可以回收，并且/或不含金属。这将通过天然产品衍生的DI-或多功能的构建块，多个或多个锁定的多组分反应 - 在本质上 - 主要是ugi-Type-新的环化过程（通过多组分和酶催化的环化反应），对新的催化系统的多催化系统的研究，用于多种成分和组合。