Diagnostic imaging of atherosclerosis using mannan-coated superparamagnetic iron oxide particles

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We performed comparative study of mannan-coated ultrasmall superparamagnetic iron oxide(mannan-coated USPIO), mannandextran-coated USPIO, and dextran-coated USPIO in the uptake bythe atherosclerotic wall using MRI and histology. Our histological and imaging analyses showed that mannan-coated USPIO and mannandextran-coated USPIO were taken up to a greater degree than dextran-coated USPIO. We suggest that mannan-coated particles are useful for the atherosclerotic imaging.