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Expression of cellular protective factors in neuronal cells after cerebral ischemia

Expression of cellular protective factors in neuronal cells after cerebral ischemia
脑缺血后神经元细胞保护因子的表达
批准号:
21791344
负责人:
SAITO Atsushi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

项目摘要

项目成果

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相关文献

中文摘要
翻译
本文以颈动脉粥样硬化病变作为脑缺血的靶点之一,对其病理生理状态进行了研究。本研究的目的是:一是检测凝集素样低密度脂蛋白受体1(LOX1)在大鼠颈动脉斑块中的表达,二是建立以LOX1为靶点的颈动脉粥样硬化靶向给药系统。脂质体法舒地尔表面偶联抗LOX 1抗体是新开发的,选择性蓄积新药,有效抑制颈动脉斑块的消除。新的脂质体法舒地尔特异性地积聚在颈动脉病变处,并且在静脉内施用脂质体法舒地尔与LOX1抗体后显著抑制斑块扩展。
英文摘要
We focused on pathophysiological states of carotid atherosclerotic lesion as one of targets of cerebral ischemia. Our purposes were first, evaluation of expression of lectin-like low density lipoprotein receptor 1 (LOX1) in rat carotid plaque, second, establishment of targeting drug delivery system for carotid atherosclerotic lesion using LOX1. Liposomal fasudil conjugated with anti-LOX1 antibody on the surface was newly developed and selective accumulation of the new drug and effectiveness on inhibition of abrogation of carotid plaque. The new liposomal fasudil was specifically accumulated on the carotid lesion and plaque extension was significantly inhibited after intravenous administration of liposomal fasudil with LOX1 antibody.
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DOI: 10.1007/s00701-009-0560-6
发表时间: 2010-07-01
期刊: ACTA NEUROCHIRURGICA
影响因子: 2.4
作者: [Saito, Atsushi, Fujimura, Miki, Tominaga, Teiji]
通讯作者: Tominaga, Teiji
Immunoliposomal drug delivery system targeting lectin-like oxidized low density lipoprotein receptor 1 for carotid plaque lesion in rats
靶向凝集素样氧化低密度脂蛋白受体1的免疫脂质体药物递送系统治疗大鼠颈动脉斑块病变
DOI: --
发表时间: 2011
期刊: Journal of Neurosurgery
影响因子: 4.1
作者: [Atsushi Saito, et al.]
通讯作者: et al.
頚動脈プラークに対する新たな drug delivery system の試み
颈动脉斑块新型药物输送系统的试验
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [斉藤敦志]
通讯作者: 斉藤敦志
頚動脈プラークに対する新たなdrug delivery systemの試み
颈动脉斑块新型药物输送系统的试验
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: []
通讯作者:
共 6 条
    Development of 100 W-class superconducting transmit filter
    • 批准号:
      24560393
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      SAITO Atsushi
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    The elucidation of the pathogenesis of dysphagia in amyotrophic lateral sclerosis -Using model mice-
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      23791921
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.16万
    • 财政年份:
      2011
    • 负责人:
      SAITO Atsushi
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    New therapeutic strategy with SMTP for acute cerebral ischemia
    • 批准号:
      23791582
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2011
    • 负责人:
      SAITO Atsushi
    • 依托单位:
    A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation
    • 批准号:
      22592317
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.25万
    • 财政年份:
      2010
    • 负责人:
      SAITO Atsushi
    • 依托单位:
    海外基金