Expression of cellular protective factors in neuronal cells after cerebral ischemia

本文以颈动脉粥样硬化病变作为脑缺血的靶点之一，对其病理生理状态进行了研究。本研究的目的是：一是检测凝集素样低密度脂蛋白受体1（LOX1）在大鼠颈动脉斑块中的表达，二是建立以LOX1为靶点的颈动脉粥样硬化靶向给药系统。脂质体法舒地尔表面偶联抗LOX 1抗体是新开发的，选择性蓄积新药，有效抑制颈动脉斑块的消除。新的脂质体法舒地尔特异性地积聚在颈动脉病变处，并且在静脉内施用脂质体法舒地尔与LOX1抗体后显著抑制斑块扩展。

We focused on pathophysiological states of carotid atherosclerotic lesion as one of targets of cerebral ischemia. Our purposes were first, evaluation of expression of lectin-like low density lipoprotein receptor 1 (LOX1) in rat carotid plaque, second, establishment of targeting drug delivery system for carotid atherosclerotic lesion using LOX1. Liposomal fasudil conjugated with anti-LOX1 antibody on the surface was newly developed and selective accumulation of the new drug and effectiveness on inhibition of abrogation of carotid plaque. The new liposomal fasudil was specifically accumulated on the carotid lesion and plaque extension was significantly inhibited after intravenous administration of liposomal fasudil with LOX1 antibody.