Expression of cellular protective factors in neuronal cells after cerebral ischemia

我们关注颈动脉粥样硬化病变的病理生理状态作为脑缺血的靶点之一。我们的目的一是评估凝集素样低密度脂蛋白受体1 （LOX1）在大鼠颈动脉斑块中的表达，二是利用LOX1建立针对颈动脉粥样硬化病变的靶向给药系统。法舒地尔脂质体表面偶联抗lox1抗体是新开发的选择性积累的新药物，对颈动脉斑块的清除具有抑制作用。新脂质体法舒地尔在颈动脉病变上特异性积累，经LOX1抗体静脉给予法舒地尔脂质体后，斑块扩展明显受到抑制。

We focused on pathophysiological states of carotid atherosclerotic lesion as one of targets of cerebral ischemia. Our purposes were first, evaluation of expression of lectin-like low density lipoprotein receptor 1 (LOX1) in rat carotid plaque, second, establishment of targeting drug delivery system for carotid atherosclerotic lesion using LOX1. Liposomal fasudil conjugated with anti-LOX1 antibody on the surface was newly developed and selective accumulation of the new drug and effectiveness on inhibition of abrogation of carotid plaque. The new liposomal fasudil was specifically accumulated on the carotid lesion and plaque extension was significantly inhibited after intravenous administration of liposomal fasudil with LOX1 antibody.