A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation
A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation
批准号:
22592317
负责人:
SAITO Atsushi
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In order to gain insight into the mechanism and significance of host cell invasion by periodontal bacteria in polymicrobial infecti on, we assessedPorphyromonas gingivalis invasion of gingival epithelial cells enhanced by Fusobacterium nucleatum. Confocal scanning laser microscopy and antibiotic protection assay were used to study the role of P. gingivalis invasin (SerB) in this phenomena. The results from the experiment using SerB-mutant strain showed that the P. gingivalis invasin does not play a major role in this phenomenon. It was demonstrated that lipid raft was involved in fusobacterial enhancement of P. gingivalis invasion.
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細菌における免疫回避機構の解明
阐明细菌的免疫逃避机制
DOI:
--
发表时间:
2013
期刊:
平成 24 年度東京歯科大学口腔科学研究センターワークショップ, 平成 25 年 3月 1 日,千葉市美浜区. 平成 24 年度東京歯科大学口腔科学研究センターワークショップ プログラムおよび抄録集
影响因子:
--
作者:
[Takehisa Ohbayashi, Atsushi Irie,Yoji Murakami, Jan Potempa,Masanori Shinohara,Takahisa Imamura, 齋藤 淳,加藤哲男,菊池有一郎,国分栄仁,今村健太郎]
通讯作者:
齋藤 淳,加藤哲男,菊池有一郎,国分栄仁,今村健太郎
Periodontopathic biofilm formation of Fusobacterium nucleatum with Prevotella intermedia, Prevotella nigrescens
具核梭杆菌与中间普雷沃氏菌、黑普氏菌的牙周病生物膜形成
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Okuda T, et al]
通讯作者:
et al
Polymicrobial感染における歯周病原性菌Porphyromonas gingivalisの宿主細胞への侵入について
多种微生物感染期间牙周病原体牙龈卟啉单胞菌侵入宿主细胞
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[齋藤淳, 稲垣覚, 国分栄仁, 君塚隆太, 石原和幸]
通讯作者:
石原和幸
歯科における最近の抗菌薬の使い方,考え方5.歯周病治療と抗菌薬-宿主に潜む歯周病原細菌への対応
抗菌剂在牙科中的最新应用,概念 5. 牙周病治疗和抗菌剂 - 应对潜伏在宿主体内的牙周病原菌
DOI:
--
发表时间:
2011
期刊:
歯科医療
影响因子:
--
作者:
[Takano M, Nishihara R, Sugano N, Matsumoto K, Yamada Y, Takane M, Fujisaki Y, Ito K., 齋藤淳]
通讯作者:
齋藤淳
歯科における最近の抗菌薬の使い方,考え方 5. 歯周病治療と抗菌薬 宿主に潜む歯周病原細菌への対応
抗菌药物在口腔医学中的最新应用与思考 5. 牙周病治疗与抗菌药物 应对潜伏在宿主体内的牙周病原菌
DOI:
--
发表时间:
2011
期刊:
歯科医療
影响因子:
--
作者:
[Nakao R, Takigawa S, Sugano N, Koshi R, Ito K, Watanabe H, Senpuku H., 齋藤 淳]
通讯作者:
齋藤 淳
共 14 条
Development of 100 W-class superconducting transmit filter
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批准号:24560393
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:SAITO Atsushi
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依托单位:
The elucidation of the pathogenesis of dysphagia in amyotrophic lateral sclerosis -Using model mice-
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批准号:23791921
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.16万
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财政年份:2011
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负责人:SAITO Atsushi
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依托单位:
New therapeutic strategy with SMTP for acute cerebral ischemia
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批准号:23791582
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2011
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负责人:SAITO Atsushi
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依托单位:
The analysis of the differentiation and function of the cells in central nervous system regulated by endoplasmic reticulum stress response.
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批准号:22800049
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项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$2.01万
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财政年份:2010
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负责人:SAITO Atsushi
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依托单位:
Development of high-performance transmit filter using superconducting bulk
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批准号:21760246
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2009
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负责人:SAITO Atsushi
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依托单位:
Expression of cellular protective factors in neuronal cells after cerebral ischemia
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批准号:21791344
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:SAITO Atsushi
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依托单位:
The discovery research of the vulnerability factor, which is associated with schizophrenia, through familial clustering cases of both Hermansky-Pudlak syndrome and schizophrenia.
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批准号:20790857
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2008
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负责人:SAITO Atsushi
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依托单位:
Study on the pathogenecity of tuberculosis in elderly people and development of its prevention
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批准号:15591061
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:SAITO Atsushi
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依托单位:
Study on the pathogenesis of normal flora in respiratory tract infection and on the diagnostic methods for the flora
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批准号:10670555
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1998
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负责人:SAITO Atsushi
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依托单位:
Studies on newly synthesized peptides having parasitocidal activity, and their mechanisms on host immune repsponses.
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批准号:07406014
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.04万
-
财政年份:1995
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负责人:SAITO Atsushi
-
依托单位:
Studies on the Induction of Immune Cells and Activating Mechanisms by Substances Derived from Oxoplasma Bgondii
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批准号:63480087
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.48万
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财政年份:1988
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负责人:SAITO Atsushi
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依托单位:
Study on Development of New Methods in the Treatment of Infection Caused by Intracellular Multiplied Bacteria
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批准号:61480198
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.11万
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财政年份:1986
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负责人:SAITO Atsushi
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依托单位:
海外基金