Analysis of T cell function in the nasal mucosa with chronic sinusitis

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Major bacteria causing acute and chronic sinusitis includes staphylococcus aureus, Streptococcus pneumoniae, and the Haemophilus influenza, and accepts the bacterial biofilm formation in the paranasal sinus local site, and a report that I participate in chronic inflammation is done. Recently, regulatory T cells (T reg) are known as suppressor T cells, which consist of a specific subpopulation of cells that functionally suppress activation of the immune system and maintain immune tolerance to self-antigens.In the present study, we used the nasal mucosa with chronic sinusitis or fugal sinusitis, and performed flowcytometric analysis as a preliminary study. The percentage of CD3 and CD19 cells in the nasal mucosa with chronic fugal sinusitis was higher than that with chronic sinusitis. And also, rd T cells and FoxP3 positive CD4 T cells tend to increased in the nasal mucosa with chronic fugal sinusitis was higher than that with chronic sinusitis.rd T cells and T reg cells may be related to the pathological difference between chronic sinusitis and fugal sinusitis.