Analysis of T cell function in the nasal mucosa with chronic sinusitis

慢性鼻窦炎鼻黏膜T细胞功能分析

• 批准号: 23791910
• 负责人: FUJITA Keigo
• 金额: $ 1.33万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791910/
• 关键词: 慢性副鼻腔炎; CD4 陽性 T 細胞; CD8 陽性 T 細胞; 制御性 T 細胞; CD4陽性T細胞; CD8陽性T細胞; 制御性T細胞; 浸潤型真菌症

Major bacteria causing acute and chronic sinusitis includes staphylococcus aureus, Streptococcus pneumoniae, and the Haemophilus influenza, and accepts the bacterial biofilm formation in the paranasal sinus local site, and a report that I participate in chronic inflammation is done. Recently, regulatory T cells (T reg) are known as suppressor T cells, which consist of a specific subpopulation of cells that functionally suppress activation of the immune system and maintain immune tolerance to self-antigens.In the present study, we used the nasal mucosa with chronic sinusitis or fugal sinusitis, and performed flowcytometric analysis as a preliminary study. The percentage of CD3 and CD19 cells in the nasal mucosa with chronic fugal sinusitis was higher than that with chronic sinusitis. And also, rd T cells and FoxP3 positive CD4 T cells tend to increased in the nasal mucosa with chronic fugal sinusitis was higher than that with chronic sinusitis.rd T cells and T reg cells may be related to the pathological difference between chronic sinusitis and fugal sinusitis.

引起急、慢性鼻窦炎的主要细菌包括金黄色葡萄球菌、肺炎链球菌和流感嗜血杆菌，并接受鼻窦局部部位细菌生物膜的形成，并做了我参与慢性炎症的报告。最近，调节性T细胞（T reg）被称为抑制性T细胞，它由一个特定的细胞亚群组成，功能上抑制免疫系统的激活和维持对自身抗原的免疫耐受。慢性真菌性鼻窦炎患者鼻粘膜中CD 3、CD 19细胞的百分比高于慢性鼻窦炎患者。慢性真菌性鼻窦炎患者鼻粘膜中rd T细胞和FoxP3阳性CD4 T细胞均较慢性鼻窦炎患者增多，rd T细胞和T reg细胞的变化可能与慢性鼻窦炎和真菌性鼻窦炎的病理差异有关。

项目成果

慢性中耳炎症病態における Th17 細胞および IL-17 産生γδT 細胞の動態

慢性中耳炎症中 Th17 细胞和产生 IL-17 的 γδT 细胞的动态

• 发表时间: 2013
• 期刊: 耳科学会
• 作者: 平野 隆;児玉 悟;川野利明;森山宗仁;藤田佳吾;鈴木正志
• 通讯作者: 鈴木正志

インフルエンザ菌位相変異による phosphorylcholine(PC)の中耳粘膜への影響

流感嗜血杆菌相位变异导致磷酸胆碱（PC）对中耳粘膜的影响

• 发表时间: 2011
• 作者: 平野 隆;児玉 悟;川野利明;森山宗仁;藤田佳吾;鈴木正志;岩崎太郎,平野 隆,児玉 悟,川野利明,藤田佳吾,鈴木正志
• 通讯作者: 岩崎太郎,平野 隆,児玉 悟,川野利明,藤田佳吾,鈴木正志