Primary bone graft for cleft lip and palate using umbilical cord-derived mesenchymal stem cells

唇腭裂的产前诊断是准确的。我们研究了出生时采集的脐带间充质干细胞用于原发性牙龈骨膜成形术和出生后3至6个月骨移植的临床适用性。第二次骨移植，这是通常在患者5至10岁时使用髂骨松质骨，提供了良好的结果。我们的研究结果表明，脐带来源的间充质干细胞的质量不同于髂骨松质骨来源的间充质干细胞，因为脐带来源的间充质干细胞分化成骨细胞是难以实现的。我们检测到脐带间充质干细胞移植模型和非细胞移植模型中的骨形成之间没有差异，使用裸鼠部分上颌骨缺损。受体生态位的研究可能与细胞质量一样重要。

Prenatal diagnosis of cleft lip and palate is accurate. We investigated the clinical applicability of umbilical cord-derived mesenchymal stem cells harvested at birth for primary gingivoperiosteoplasty and bone grafting 3 to 6 months after birth. Secondary bone grafting, which is usually performed when the patient is 5 to 10 years old using iliac cancellous bone, provides good results.Our findings revealed that the quality of umbilical cord-derived mesenchymal stem cells differed from that of iliac cancellous bone-derived mesenchymal stem cells, because differentiation of umbilical cord-derived mesenchymal stem cells into bone cells was difficult to achieve. We detected no difference between the bone formations in the umbilical cord-derived mesenchymal stem cell graft model and those of the non-cell graft model using the nude mouse with partial maxillary defects. Studies of the recipient niche might be as important as the cell quality.