Protein secretion system in Periodonto-pathic Bacteria

革兰氏阴性菌牙龈卟啉单胞菌具有许多潜在的牙周病致病性毒力因子。特别是，半胱氨酸蛋白酶，被称为牙龈蛋白酶，是重要的毒力因子，因为它可以降解宿主蛋白，并负责处理/成熟牙龈卟啉卟啉毒力因子。PorSS参与含有CTD的蛋白质的分泌，这些蛋白质对牙龈卟啉菌的菌落色素沉着、血凝、粘附和细菌病原体的毒力至关重要。

The gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. Particulary, cysteine proteases, named gingipains, are important virulence factors because of degradation of host proteins and responsibility for processing/maturation of P. gingivalis virulence factors. The PorSS is involved in the secretion of the proteins containing CTD that are essential for colony pigmentation, hemeagglutination, adherence, and virulence of bacterial pathogen of P. gingivalis.