Protein secretion system in Periodonto-pathic Bacteria

牙周病细菌的蛋白质分泌系统

• 批准号: 23792109
• 负责人: SATO Keiko
• 金额: $ 2.75万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792109/
• 关键词: 歯周病; 病原因子; 細菌学; プロテアーゼ; 細菌; タンパク質分泌

The gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity. Particulary, cysteine proteases, named gingipains, are important virulence factors because of degradation of host proteins and responsibility for processing/maturation of P. gingivalis virulence factors. The PorSS is involved in the secretion of the proteins containing CTD that are essential for colony pigmentation, hemeagglutination, adherence, and virulence of bacterial pathogen of P. gingivalis.

牙龈卟啉单胞菌是一种革兰氏阴性菌，具有多种致病性。特别是，半胱氨酸蛋白酶，称为牙龈卟啉菌蛋白酶，是重要的毒力因子，因为降解宿主蛋白质和负责牙龈卟啉单胞菌毒力因子的加工/成熟。PorSS参与含有CTD的蛋白质的分泌，所述CTD对于牙龈卟啉单胞菌的细菌病原体的菌落色素沉着、血凝、粘附和毒力是必需的。

项目成果

Secretion and Gliding in Bacteroides

拟杆菌的分泌和滑动

• 发表时间: 2012
• 作者: Sato K;Nakane D;Wada H;Imada K;M. McBride;Nakayama K (Sato K)
• 通讯作者: Nakayama K (Sato K)

Identification of Porphyromonas gingivalis proteins secreted by Por secretion system.

Por分泌系统分泌的牙龈卟啉单胞菌蛋白的鉴定。

• 作者: Keiko Sato;Hideharu Yukitake;Yuka Narita;Mariko Naito;Mikio Shoji;Koji Nakayama
• 通讯作者: Koji Nakayama