バクテロデスフィラムに位置する細菌の菌体外蛋白質分泌機構の解明

牙龈卟啉单胞菌（Porphyromonas gingivalis）是一种口腔厌氧菌，与牙周病的发病密切相关。大多数细胞外和细胞表面蛋白酶的蛋白水解活性来源于半胱氨酸蛋白酶，称为牙龈卟啉菌蛋白酶。我们发现了一种新的蛋白质分泌系统中的细菌的门拟杆菌，这是负责分泌的毒力因子，如牙龈卟啉菌蛋白酶产生的牙周病原体牙龈卟啉单胞菌，并与拟杆菌滑动运动，这是不同的其他充分研究的形式的细菌运动。

Porphyromonas gingivalis is an oral anaerobic Gram-negative bacterium, which is implicated in periodontal pathogenesis. Most of proteolytic activity of extracellular and cell-surface proteinase are derived from cysteine proteinase named gingipains. We found a novel protein secretion system in bacteria of the phylum Bacteroidetes, which is responsible for secretion of virulence factors such as gingipain proteinases produced from the periodontal pathogen Porphyromonas gingivalis and is linked to bacteroidete gliding motility that is distinct from other well-studied forms of bacterial movement.