Development of controlled release of vancomycin sol-gel films on titanium abutment

钛基台万古霉素溶胶凝胶膜控释技术的研制

• 批准号: 23792219
• 负责人: KOBAYASHI Yasuyoshi
• 金额: $ 2.5万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792219/
• 关键词: インプラント; 表面加工; チタン合金; チタン; 抗菌加工

Sol-gel films on titanium alloy have made with vancomycin solution. In the solution of more than 10% weight concentration vancomycin, about three weeks was confirmed in the study of controlled release drug release of the film.In the morphological analysis, the stability of the films can be acquired at a thickness of 200nm revealed.To investigate the antibacterial coating, we examined the effect on the formation of the inhibition rings by immersion in a saliva 37 ℃. Formation of inhibition rings was reduced after 14 days.

用万古霉素溶液在钛合金表面制备了溶胶凝胶膜。在质量浓度大于10%的万古霉素溶液中，药物控释研究持续了约3周。在形态分析中，薄膜在200 nm的厚度下可以获得稳定性。为了研究抗菌涂层，我们考察了在37℃的唾液中浸泡对抑制环形成的影响。14d后抑制环的形成减少。