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Application to the treatment and analysis of oral cancer metastasis mechanism by ADAM17 activity

Application to the treatment and analysis of oral cancer metastasis mechanism by ADAM17 activity
ADAM17活性在口腔癌治疗及转移机制分析中的应用
批准号:
23792362
负责人:
TAKAMUNE Yasuo
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
通过转化成熟形式的前体金属蛋白酶ADAM-17,TNFα揭示了切割粘附分子CD 44,促进口腔鳞癌细胞的侵袭。本次,针对腺样囊性癌是涎腺癌的一种类型,对其活性和ADAM-17,在蛋白水平上进行了分析,发现它们存在和CD 44的意义,但可以发现没有明确的表达。
英文摘要
By converting the mature form of the proform metalloprotease ADAM-17, TNFα revealed that cutting the adhesion molecule CD44, invasion of oral squamous cell carcinoma cells to promote. This time, in view of the adenoid cystic carcinoma is a type of salivary gland cancer, its activity and ADAM-17, was analyzed at the protein level significance of their existence and CD44, but can be found a clear expression did not.
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DOI: 10.1111/j.1349-7006.2011.02174.x
发表时间: 2012-03
期刊: Cancer Science
影响因子: 5.7
作者: [Takuya Tanaka;H. Nakayama;Y. Yoshitake;A. Irie;M. Nagata;K. Kawahara;Y. Takamune;R. Yoshida;Y. Nakagawa;Hidenao Ogi;S. Shinriki;K. Ota;A. Hiraki;T. Ikebe;Y. Nishimura;M. Shinohara]
通讯作者: Takuya Tanaka;H. Nakayama;Y. Yoshitake;A. Irie;M. Nagata;K. Kawahara;Y. Takamune;R. Yoshida;Y. Nakagawa;Hidenao Ogi;S. Shinriki;K. Ota;A. Hiraki;T. Ikebe;Y. Nishimura;M. Shinohara
DOI: --
发表时间: 2012
期刊: Oral Science International
影响因子: 0.5
作者: [Tetsuro Ikebe, Keiko Yamasaki, Yasuo Takamune, Hideki Nakayama, Masanori Shinohara]
通讯作者: Masanori Shinohara
Analysis of the mechanism of metastasis mediated ADAM-17 in adenoid cystic carcinoma.
  • 批准号:
    21792018
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2009
  • 负责人:
    TAKAMUNE Yasuo
  • 依托单位:
海外基金