Expression analysis of DKK gene and development of a molecular targeted therapy for oral cancer
Expression analysis of DKK gene and development of a molecular targeted therapy for oral cancer
DKK基因表达分析及口腔癌分子靶向治疗开发
批准号：
23792365
负责人：
SOGABE Yohei
金额：
$2.66万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
中文摘要
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英文摘要
In the present study, we examined the relationship between Wnt signaling and epigenetic alteration of the Dickkopf-related protein (DKK) genes in oral squamous cell carcinomas (OSCC). Our result confirms the frequent methylation and silencing of DKK genes in OSCC, and suggest that their loss of function contributes to activation of Wnt signaling that leads to cell proliferation during oral carcinogenesis.
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Expression analysis of SFRP family genes for development of molecular targeted therapy for oral cancer
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批准号：21792021
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.75万
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财政年份：2009
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负责人：SOGABE Yohei
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依托单位：
海外基金
