The effects of IL-17-RANKL on root resorption during orthodontic tooth movement

IL-17-RANKL对正畸牙齿移动过程中牙根吸收的影响

• 批准号: 23792449
• 负责人: FUJITA Shoji
• 金额: $ 1.91万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792449/
• 关键词: 歯科矯正; 歯根吸収; IL-17-RANKL; 歯科矯正学; IL-17; RANKL

The immunoreactivities for TRAP, IL-17, IL-6, and RANKL in the アトピー性皮膚炎 (atopic dermatitis: AD) group were found to be significantly increased. The double-immunofluorescence analysis for IL-17/CD4 detected immunoreaction. The secretion of IL-17, IL-6 and RANKL, and the mRNA levels of IL-6 and RANKL in the AD patients were increased compared with those in healthy individuals.Conclusion: Th17 cells may therefore be associated with the deterioration of root resorption of AD mice, and may explain why AD patients are more susceptible to root resorption than healthy individuals when the heavy OF is applied.

The immunoreactivities for TRAP, IL-17, IL-6, and RANKL in the <$opic dermatitis (AD) group were found to be significantly increased. The double-immunofluorescence analysis for IL-17/CD4 detected immunoreaction. The secretion of IL-17, IL-6 and RANKL, and the mRNA levels of IL-6 and RANKL in the AD patients were increased compared with those in healthy individuals.Conclusion: Th17 cells may therefore be associated with the deterioration of root resorption of AD mice, and may explain why AD patients are more susceptible to root resorption than healthy individuals when the heavy OF is applied.

项目成果

アレルギーは矯正学的歯の移動時に生じる歯根吸収を増悪する

过敏会加剧正畸牙齿移动过程中发生的牙根吸收。

• 发表时间: 2012
• 作者: 山田邦彦;山口大;小林良喜;浅野正貴;安藤淳;宇都宮忠彦;山本正文;山本浩嗣;葛西一貴
• 通讯作者: 葛西一貴

Orthodontic Root Resorption was Associated with the Secretion of IL-6 and IL-8 Stimulated by IL-17in Dental Pulp Cells

• DOI: 10.5466/ijoms.11.172
• 发表时间: 2013
• 期刊: International Journal of Oral-Medical Sciences
• 作者: Mami Shimizu;M. Yamaguchi;M. Asano;S. Fujita;T. Utsunomiya;Hirotsugu Yamamoto;K. Kasai

矯正学的歯の移動時に生じる歯根吸収におけるhelper T cell17の関与

辅助 T 细胞 17 参与正畸牙齿移动过程中发生的牙根吸收

• 发表时间: 2011
• 作者: 清水 真美;山口 大;浅野 正貴;葛西 一貴;山田邦彦,山口大,藤田祥仁,浅野正貴,安藤淳,宇都宮忠彦,山本浩嗣,葛西一貴.
• 通讯作者: 山田邦彦,山口大,藤田祥仁,浅野正貴,安藤淳,宇都宮忠彦,山本浩嗣,葛西一貴.

Th17-cells in atopic dermatitis stimulate orthodontic root resorption.

特应性皮炎中的 Th17 细胞刺激正畸牙根吸收。

• DOI: 10.1111/odi.12053
• 发表时间: 2012
• 期刊: Oral Dis
• 影响因子: 3.8
• 作者: Yamada K;Yamaguchi M;Asano M;FujitaS;Kobayashi R;Kasai K.
• 通讯作者: Kasai K.

Morphological and Histological Changes in the Mandibular Condyle after Plate Removal in Experimental Models of Short- and Long-term Mandibular Lateral Displacement

短期和长期下颌横向位移实验模型中钢板去除后下颌髁突的形态学和组织学变化

• DOI: 10.2485/jhtb.22.201
• 发表时间: 2013
• 期刊: Journal of Hard Tissue Biology
• 影响因子: 0.4
• 作者: Junji Ando;M. Yamaguchi;Shouji Fujita;Aya Kawamura;T. Utsunomiya;K. Kasai
• 通讯作者: K. Kasai