Development of novel vaccine delivery systems for induction of mucosal immunity in a large animal model

诱导粘膜免疫反应是疫苗研究和开发的一个非常理想的目标，因为它可以防止大量粘膜病原体的进入。本研究旨在开发新的粘膜疫苗递送系统，将iscom佐剂与鼻内、肺内和经皮疫苗递送相结合。免疫反应的性质将使用绵羊插管模型实时分析。随后，粘膜疫苗接种策略的有效性将在衣原体感染模型中进行测试。

The induction of mucosal immune responses is a highly desirable goal in vaccine research and development, as it prevents entry of the large number of mucosal pathogens. This proposal aims to develop new mucosal vaccine delivery systems by combining intra-nasal, intra-lung and transcutaneous vaccine delivery with ISCOM-based adjuvants. The nature of the immune response will be analysed in real time using a sheep cannulation model. Subsequently, the efficacy of mucosal vaccination strategies will be tested in a chlamydia infection model.