Understanding immune mechanisms induced by pulmonary vaccination

了解肺部疫苗接种诱导的免疫机制

• 批准号: LP100200728
• 负责人: Prof Jean-Pierre Scheerlinck
• 金额: $ 23.45万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-21 至 2014-01-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100200728
• 关键词: Understanding; immune; mechanisms; induced; pulmonary

This project aims to better understand the mechanisms of immune induction of a novel lung vaccination strategy. The ability to deliver vaccines that induce potent lung and body wide immune responses in a safe and efficient manner has wide implications for both human and animal health. Ultimately, the vaccine will be delivered to the lung as stable dry powders in an attempt to negate the need for a transport cold chain and therefore facilitate the distribution of the vaccines to remote areas. The project will not only benefit the Australian biotechnology industry but also the community at large and in particular those in remote areas without access to modern medical facilities.

该项目旨在更好地了解新型肺部疫苗接种策略的免疫诱导机制。以安全有效的方式提供诱导有效的肺部和全身免疫反应的疫苗的能力对人类和动物健康具有广泛的影响。最终，疫苗将以稳定的干粉形式输送到肺部，从而消除对运输冷链的需求，从而促进将疫苗分发到偏远地区。该项目不仅有利于澳大利亚生物技术行业，也有利于整个社区，特别是那些无法获得现代医疗设施的偏远地区的人们。