Investigation of the resilience of immune memory to manipulation by pathogens

免疫记忆对病原体操纵的恢复能力的研究

• 批准号: DP1094465
• 负责人: Prof Jean-Pierre Scheerlinck
• 金额: $ 25.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094465
• 关键词: Investigation; resilience; immune; memory; manipulation

Vaccines have a major impact on the wellbeing of humans as well as productivity and welfare of veterinary species and pets. New vaccines have therefore a tremendous effect on both the economy and the community. Here we investigate in how far an adjuvanted vaccine can influence the type of immune response induced during subsequent infection when the pathogen has developed mechanisms to subvert the induced protective immune response. This question has profound implications for all vaccine and adjuvant development activities, as the resilience of immune memory is not yet considered an important parameter in the design of adjuvants yet it is fundamental to the successful of vaccines against many pathogens.

疫苗对人类的福祉以及兽医物种和宠物的生产力和福利有重大影响。因此，新疫苗对经济和社区都有巨大的影响。在这里，我们调查在多大程度上，当病原体已经发展出破坏诱导的保护性免疫反应的机制时，佐剂疫苗可以在多大程度上影响随后感染期间诱导的免疫反应类型。这个问题对所有疫苗和佐剂开发活动都有深远的影响，因为免疫记忆的弹性尚未被认为是佐剂设计中的一个重要参数，但它是针对许多病原体的疫苗成功的基础。