Investigation of the immunological properties of a novel adjuvant in sheep.

诱导强免疫应答而无副作用是疫苗研发中非常期望的目标。最近开发的佐剂DCtag利用树突状细胞的独特特性来增强细胞和体液免疫应答而不损伤组织。本项目将使用我们的绵羊插管模型的独特特性来确定DCtag的免疫诱导机制。这将允许进一步优化绵羊中的DCtag佐剂性，然后将其应用于针对口蹄疫病毒（一种全球重要的兽医疾病）的原型肽疫苗的递送，从而提高澳大利亚在生物技术方面的领导地位。

The induction of strong immune responses without side effects is a highly desirable goal in vaccine R&D. The recently developed adjuvant DCtag utilises unique properties of dendritic cells to boost both cellular and humoral immune responses without tissue damage. This project will identify the mechanisms of immune induction of DCtag using unique properties of our sheep cannulation model. This will allow further optimisation of DCtag adjuvanticity in sheep, which will then be applied to the delivery of a prototype peptide based vaccine against foot and mouth disease virus, a veterinary disease of global importance, hereby increasing Australia's leadership in biotechnology.