Study on the mechanisms of mitochondrial maintenance by cooperation of proteolysis machineries
Study on the mechanisms of mitochondrial maintenance by cooperation of proteolysis machineries
批准号:
23770239
负责人:
TAKEDA Kojiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
In order to identify proteolysis factors, which are involved in maintaining mitochondrial quality, genetic screening was carried out, using Schizosaccharomyces pombe as a model organism. As a result, one potential E3 ubiquitin ligase (RING finger type) was identified to be required for mitochondrial morphology, mitophagy, and maintenance of life span of S.pombe cells in G0/quiescent phase.
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分裂酵母26Sプロテアソーム核/核膜局在化因子Cut8の持つ14-3-3タンパク質様のユニークな構造とその核膜局在化における役割
裂殖酵母26S蛋白酶体核/核膜定位因子Cut8独特的14-3-3类蛋白结构及其在核膜定位中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kojiro Takeda, Nam K tonthat, Tiffany Glover, Weijun Xu, Eugene V. Koonin, Mitsuhiro Yanagida and Maria Schumacher., 武田鋼二郎, 武田鋼二郎]
通讯作者:
武田鋼二郎
抗がん剤ボルテゾミブ添加と合成致死となる分裂酵母遺伝子破壊株の単離
抗癌药物硼替佐米的添加及合成致死裂殖酵母基因破坏菌株的分离
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kojiro Takeda, Nam K tonthat, Tiffany Glover, Weijun Xu, Eugene V. Koonin, Mitsuhiro Yanagida and Maria Schumacher., 武田鋼二郎,森礼郁,柳田充弘.]
通讯作者:
武田鋼二郎,森礼郁,柳田充弘.
The nuclear proteasome tethering factor Cut8 directly binds to the nuclear envelope through 14-3-3-like structure
核蛋白酶体束缚因子 Cut8 通过 14-3-3 样结构直接与核膜结合
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kojiro Takeda, Nam K tonthat, Tiffany Glover, Weijun Xu, Eugene V. Koonin, Mitsuhiro Yanagida and Maria Schumacher.]
通讯作者:
Mitsuhiro Yanagida and Maria Schumacher.
DOI:
10.1371/journal.pone.0022021
发表时间:
2011
期刊:
PloS one
影响因子:
3.7
作者:
[Takeda K, Mori A, Yanagida M]
通讯作者:
Yanagida M
Mis17 is a regulatory models of the Mis6-Mal2-Sim4 centromere complexthat is required for the recruitment of CenH3/CENP-Ain fissionyeast
Mis17 是 Mis6-Mal2-Sim4 着丝粒复合物的调控模型,是招募 CenH3/CENP-Ain 裂殖酵母所需的
DOI:
--
发表时间:
2011
期刊:
PLoS One
影响因子:
3.7
作者:
[Shiroiwa, Y., Hayashi, T., Fujita, Y., Villar-Briones, A., Ikai, N., Takeda, K., Ebe, M., and Yanagida,M.]
通讯作者:
and Yanagida,M.
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Research on factors of the ubiquitin/proteasome system required for maintaining the nuclear homeostasis in the quiescence
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批准号:20770167
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.5万
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财政年份:2008
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负责人:TAKEDA Kojiro
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依托单位:
海外基金