regulations of muscle cells in limb regeneration in axolotl limb regeneration

点击翻译按钮获取中文摘要

It has been believed that regenerated limb must be consisted of limb derived cells. But recent our studies imply that muscle cells are not in the case. To investigate whether non-limb derived muscle cells can participate into limb regeneration, we improved our novel experimental system, called the accessory limb model. The improved accessory limb model is an ideal experimental system to investigate limb regeneration. We first revealed dynamics of expression of muscle marker genes. Then, we tested whether tail muscle (non-limb origin) cells could participate into limb regeneration. Our results indicate that non-limb derived muscle cells makes limb muscles in limb regeneration as we expected. Those results are quite useful and insightful for understanding limb regeneration. moreover, our knowledge can provide a novel insights into limb muscle evolution.